NRAS p.Gly60=
c.180A>G · rs2526451431 · VCV1723142
Uncertain significance
No assertion criteria
Classification
Uncertain significance
ClinVar
Review
No assertion criteria ☆☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Absent
absent from gnomAD v4.1
Conditions
1
prostate cancer, hereditary, 1
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation carries the signal. | ||
| Splicing | ||
| SpliceAI | — | not assessed · no allele here is in the release |
|---|---|---|
| Constraint at this position | ||
| Conservation | phyloP 0.21 | GERP -1.4, phastCons 0.99 |
| Overall | ||
| CADD | 10.46 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.
Variant & gene context
- Gene
- NRAS
- Protein
- p.Gly60=
- Coding
- c.180A>G
- MANE Select
- NM_002524
- dbSNP
- rs2526451431
- Type
- single nucleotide variant
- Location
- chr1:114713910 (GRCh38)
- Gene constraint
- LOEUF 0.55 · pLI 0.94 · ClinGen HI 0/3 (gnomAD)
- Structure
- AlphaFold pLDDT 92.56 · 36 PDB
- Residue 60
- a UniProt-annotated variant site (in ns6; hypermorphic mutation); a binding site
Disease context
prostate cancer, hereditary, 1 — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatmentsFor Familial prostate cancer (Orphanet):
- Inheritance
- Not applicable
- Onset
- Adult
- Prevalence
- 1-9 / 100 000 (United States)
Similar variants
- NRAS p.Gly60Glu Pathogenic ★★★ same residue
- NRAS p.Gly60Arg Likely pathogenic ★★ same residue
- NRAS p.Gly60Val Conflicting classifications of pathogenicity ★ ⚠ same residue
- NRAS p.Ile55Thr Uncertain significance ⚠ same condition
- NRAS p.Gly12Ser Pathogenic ★★★ same type
- NRAS p.Ile24Asn Likely pathogenic ★★★ same type
- NRAS p.Thr50Ile Pathogenic ★★★ ⚠ same type
- NRAS p.Thr58Ile Pathogenic ★★★ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/nras-p-gly60 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown