Is PRODH p.Ala58= (c.174G>T) pathogenic?

PRODH p.Ala58= (c.174G>T) is classified Likely benign in PRODH (ClinVar, Multiple submitters, 3 submitters; last evaluated 2024-10-21). No allele count reported in gnomAD v4.1; Associated with schizophrenia 4.

What condition is associated with PRODH p.Ala58= (c.174G>T)?

PRODH p.Ala58= (c.174G>T) is associated with schizophrenia 4, hyperprolinemia type 1 (ClinVar).

How common is PRODH p.Ala58= (c.174G>T) in the general population?

PRODH p.Ala58= (c.174G>T) is no allele count reported in gnomAD v4.1 (gnomAD).

PRODH p.Ala58=

c.174G>T · rs931875471 · VCV1549874

Likely benign Multiple submitters

Classification

Likely benign

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 3 submitters

gnomAD v4.1

Not reported

no allele count reported in gnomAD v4.1

Conditions

schizophrenia 4

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
REVEL	0.084	moderately benign-leaning
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP -3.6	GERP -2
Overall
CADD	6.363	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

No allele count reported in gnomAD v4.1. This is missing data, not an absence: the variant may or may not be present in gnomAD. Rarity (ACMG PM2) and BA1/BS1 cannot be assessed for it.

Variant & gene context

Gene: PRODH
Protein: p.Ala58=
Coding: c.174G>T
MANE Select: NM_016335
dbSNP: rs931875471
Type: single nucleotide variant
Location: chr22:18936114 (GRCh38)
Structure: AlphaFold pLDDT 85.29
Residue 58: a UniProt-annotated variant site (in)

Full PRODH gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

schizophrenia 4 — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: hyperprolinemia type 1

Similar variants

PRODH p.Ala58Thr Benign/Likely benign ★★ same residue
PRODH c.1104+2T>C Likely pathogenic ★★ same condition
PRODH p.Gln59Ter Pathogenic/Likely pathogenic ★★ same condition
PRODH p.Tyr412Ter Pathogenic ★★ same condition
PRODH c.1427+4C>T Uncertain significance ★★ same condition
PRODH c.1615+1G>C Uncertain significance ★★ same condition
PRODH c.482+6G>A Uncertain significance ★★ same condition
PRODH c.929+3G>A Uncertain significance ★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/prodh-p-ala58 (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown