Is RANBP2 p.Phe592= (c.1776T>C) pathogenic?

RANBP2 p.Phe592= (c.1776T>C) is classified Likely benign in RANBP2 (ClinVar, Single submitter, 1 submitter; last evaluated 2025-03-16). Very rare (popmax 0.00772%, nfe); Associated with familial acute necrotizing encephalopathy.

What condition is associated with RANBP2 p.Phe592= (c.1776T>C)?

RANBP2 p.Phe592= (c.1776T>C) is associated with familial acute necrotizing encephalopathy (ClinVar).

How common is RANBP2 p.Phe592= (c.1776T>C) in the general population?

RANBP2 p.Phe592= (c.1776T>C) is very rare (popmax 0.00772%, nfe) (gnomAD).

How is Familial acute necrotizing encephalopathy inherited?

Typically Autosomal dominant (Orphanet). A genetic counselor can assess individual risk for a family.

RANBP2 p.Phe592=

c.1776T>C · rs755487849 · VCV537223

Likely benign Single submitter

Classification

Likely benign

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

gnomAD v4.1

Rare

very rare (popmax 0.00772%, nfe)

Conditions

familial acute necrotizing encephalopathy

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 0.93	GERP 0.28, phastCons 1
Overall
CADD	9.906	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 0.00772% European (non-Finnish) · 91/1,178,950 alleles

Filtering AF 0.0064% ClinGen BA1/BS1 input FAF95, joint · FAF99 0.00593%

Overall 0.00628% 101/1,609,104 alleles · very rare exomes 97/1,456,950 · genomes 4/152,154 · joint denominator

Ancestry group	Frequency	1 in
European (non-Finnish)grpmax	0.00772%	12,955
South Asian	0.00663%	15,075
Remaining individualsnot grpmax-eligible	0.00322%	31,054
Finnishnot grpmax-eligible	0.00156%	63,994
African / African-American	0.00134%	74,532

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: RANBP2
Protein: p.Phe592=
Coding: c.1776T>C
MANE Select: NM_006267
dbSNP: rs755487849
Type: single nucleotide variant
Location: chr2:108753018 (GRCh38)
Gene constraint: LOEUF 0.231 · pLI 1.00 (gnomAD)

Full RANBP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

familial acute necrotizing encephalopathy — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

For Familial acute necrotizing encephalopathy (Orphanet):

Inheritance: Autosomal dominant
Onset: Adolescent, Adult, Childhood, Infancy

Similar variants

RANBP2 p.Thr585Met Pathogenic/Likely pathogenic ★★ ⚠ same condition
RANBP2 c.406-2A>G Uncertain significance ★★ same condition
RANBP2 p.Ala2564Ser Uncertain significance ★★ ⚠ same condition
RANBP2 p.Ala3072Val Uncertain significance ★★ ⚠ same condition
RANBP2 p.Ala534Val Uncertain significance ★★ same condition
RANBP2 p.Ala836Val Uncertain significance ★★ ⚠ same condition
RANBP2 p.Arg1096Gln Uncertain significance ★★ ⚠ same condition
RANBP2 p.Arg1198Cys Uncertain significance ★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/ranbp2-p-phe592 (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown