SARS2 p.Val351=
c.1053G>A · rs2513526772 · VCV2834061
Uncertain significance
Single submitter
Classification
Uncertain significance
ClinVar
Review
Single submitter ★☆☆☆
ClinVar · 1 submitter
gnomAD v4.1
Absent
absent from gnomAD v4.1
Computational evidence
| Protein change | ||
| Missense predictors do not apply to this variant type; conservation/SpliceAI carries the signal. | ||
| Splicing | ||
| SpliceAI | Δ0.35 | acceptor gain · deltas |
|---|---|---|
| Pangolin | Δ0.44 | gain · loss 0.14 · agrees with SpliceAI · independent |
| Constraint at this position | ||
| Conservation | phyloP 0.97 | GERP -0.63, phastCons 1 |
| Overall | ||
| CADD | 17.43 | PHRED · no single calibrated threshold — expert panels disagree |
Population frequency
gnomAD v4.1 · exomes + genomes
Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.
Variant & gene context
- Gene
- SARS2
- Protein
- p.Val351=
- Coding
- c.1053G>A
- MANE Select
- NM_017827
- dbSNP
- rs2513526772
- Type
- single nucleotide variant
- Location
- chr19:38917831 (GRCh38)
- Gene constraint
- LOEUF 1.02 · pLI <0.01 (gnomAD)
- Structure
- AlphaFold pLDDT 90.58 · 6 PDB
- Residue 351
- a β-strand
Similar variants
- SARS2 c.759+4T>C Uncertain significance ★★ same type
- SARS2 c.-5C>A Uncertain significance ★★ same type
- SARS2 p.Ala167Val Uncertain significance ★★ ⚠ same type
- SARS2 p.Ala463Val Uncertain significance ★★ ⚠ same type
- SARS2 p.Ala516Ser Uncertain significance ★★ ⚠ same type
- SARS2 p.Ala73Pro Uncertain significance ★★ ⚠ same type
- SARS2 p.Arg118Gln Uncertain significance ★★ ⚠ same type
- SARS2 p.Arg139Trp Uncertain significance ★★ ⚠ same type
Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →
Cite Sugi Variant
Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/sars2-p-val351 (accessed [today's date]).
Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown