Is SDHB p.Asp236= (c.708C>T) pathogenic?

SDHB p.Asp236= (c.708C>T) is classified Benign/Likely benign in SDHB (ClinVar, Multiple submitters, 2 submitters; last evaluated 2025-03-13). Very rare (popmax 8.47e-05%, nfe); Associated with hereditary neoplastic syndrome.

What condition is associated with SDHB p.Asp236= (c.708C>T)?

SDHB p.Asp236= (c.708C>T) is associated with hereditary neoplastic syndrome, pheochromocytoma/paraganglioma syndrome 4 (ClinVar).

How common is SDHB p.Asp236= (c.708C>T) in the general population?

SDHB p.Asp236= (c.708C>T) is very rare (popmax 8.47e-05%, nfe) (gnomAD).

SDHB p.Asp236=

c.708C>T · VCV3793583

Benign/Likely benign Multiple submitters

Classification

Benign/Likely benign

ClinVar

Review

Multiple submitters ★★☆☆

ClinVar · 2 submitters

gnomAD v4.1

Rare

very rare (popmax 8.47e-05%, nfe)

Conditions

hereditary neoplastic syndrome

Computational evidence

Protein change
Missense predictors do not apply to this variant type; conservation carries the signal.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 5.9	GERP 2.2, phastCons 1
Overall
CADD	11.0	PHRED · no single calibrated threshold — expert panels disagree

Population frequency

gnomAD v4.1 · exomes + genomes

Grpmax group 8.47e-05% European (non-Finnish) · 1/1,179,950 alleles

Overall 6.84e-05% 1/1,461,786 alleles · very rare

Rarity supports pathogenicity (ACMG PM2); frequency above a disease-specific BA1/BS1 threshold argues against it. A variant frequent in one ancestry group can be near-absent in others, so a single global figure can mislead.

Variant & gene context

Gene: SDHB
Protein: p.Asp236=
Coding: c.708C>T
MANE Select: NM_003000
Type: single nucleotide variant
Location: chr1:17022665 (GRCh38)
Gene constraint: LOEUF 0.741 · pLI 0.03 · ClinGen HI 3/3 (gnomAD)
Structure: AlphaFold pLDDT 92.14 · 6 PDB

Full SDHB gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Disease context

hereditary neoplastic syndrome — disease report on Sugi Atlas → Associated genes, phenotypes, clinical trials & treatments

Also linked: pheochromocytoma/paraganglioma syndrome 4

Similar variants

SDHB p.Asp236Asn Uncertain significance ★ same residue
SDHB p.Asp236Val Uncertain significance ★ ⚠ same residue
SDHB p.Asp236_Pro237insAspTer Pathogenic ★ same residue
SDHB p.Asp236Glu Conflicting classifications of pathogenicity ★ ⚠ same residue
SDHB c.200+1G>A Pathogenic ★★ same condition
SDHB c.200+1G>C Pathogenic/Likely pathogenic ★★ same condition
SDHB c.200+5G>T Likely pathogenic ★★ same condition
SDHB c.201-1G>C Pathogenic/Likely pathogenic ★★ same condition

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/sdhb-p-asp236 (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown