Is STS p.Trp367Cys (c.1101G>C) pathogenic?

STS p.Trp367Cys (c.1101G>C) is classified Uncertain significance in STS (ClinVar, Single submitter, 1 submitter; last evaluated 2024-06-02). AlphaMissense: likely pathogenic (0.9175); Absent from gnomAD v4.1.

How common is STS p.Trp367Cys (c.1101G>C) in the general population?

STS p.Trp367Cys (c.1101G>C) is absent from gnomAD v4.1 (gnomAD).

What do computational predictors say about STS p.Trp367Cys (c.1101G>C)?

AlphaMissense predicts likely pathogenic (score 0.9175) — an in-silico prediction, not a clinical call.

STS p.Trp367Cys

c.1101G>C · VCV3384537

Uncertain significance Single submitter

Classification

Uncertain significance

ClinVar

Review

Single submitter ★☆☆☆

ClinVar · 1 submitter

AlphaMissense

likely pathogenic

0.9175 · ACMG-weighted

gnomAD v4.1

Absent

absent from gnomAD v4.1

Missense predictors

3/3 damaging

AlphaMissense, REVEL, SaProt

Computational evidence

Protein change
AlphaMissense	0.9175	likely pathogenic · top 9% in STS
REVEL	0.922	moderately pathogenic-leaning
SaProt	LLR -14.47	damaging
⇒ AlphaMissense, REVEL and SaProt all call this damaging.
Splicing
SpliceAI	—	not assessed · no allele here is in the release
Constraint at this position
Conservation	phyloP 9.3	GERP 6.4, phastCons 1
Regional constraint	o/e 1.16	unconstrained · MANE · 25 kb · p 0.038 · regional, not allelic
Overall
CADD	25.5	PHRED · no single calibrated threshold — expert panels disagree

ClinVar classifies this uncertain; the computational predictors unanimously lean damaging — a triage signal, not a reclassification

AlphaMissense carries the ACMG weight for missense; REVEL and SaProt are independent agreement signals.

⚠ Isoform check: AlphaMissense numbered on a different transcript (AM W372C vs ClinVar W367C) — verify the residue.

Population frequency

gnomAD v4.1 · exomes + genomes

Absent from gnomAD v4.1. Not observed in any sequenced alleles — a rarity signal (ACMG PM2-supporting), not evidence of pathogenicity on its own.

Variant & gene context

Gene: STS
Protein: p.Trp367Cys
Coding: c.1101G>C
MANE Select: NM_001320752
Type: single nucleotide variant
Location: chrX:7325358 (GRCh38)
Structure: AlphaFold pLDDT 94.31 · 2 PDB
Residue 372 UniProt numbering: a UniProt-annotated variant site (in ixl; loss of steryl-sulfatase activity); a β-strand

Full STS gene report on Sugi Atlas → Gene function, pathways, protein structure, interactions & more

Similar variants

STS p.Trp367Ser Uncertain significance ★ ⚠ same residue
STS p.Trp367Arg Pathogenic same residue
STS p.Gly354Arg Likely pathogenic ★★ same type
STS p.Arg381Ser Uncertain significance ★★ ⚠ same type
STS p.Asp397Asn Uncertain significance ★★ ⚠ same type
STS c.1082-55C>T Likely benign ★★ same type
STS c.1082-76G>A Benign ★★ same type
STS c.1241+15G>C Benign ★★ same type

Built on 18 open, versioned datasets — ClinVar, gnomAD, AlphaMissense, REVEL, ClinGen & more — plus Sugi Variant's own cross-source analysis. Source data 2026-01–2026-10, ClinVar 2026-10. Full sources & versions →

Cite Sugi Variant

Gür T. Sugi Variant: A Deterministic Per-Variant Germline Reference from a Knowledge Graph for Humans and AI Agents. 2026. doi:10.5281/zenodo.21509445. This variant: https://sugi.bio/variant/sts-p-trp367cys (accessed [today's date]).

Preprint & method: sugi.bio/variant/method Machine-readable: this page as Markdown