SCHEMBL10000216

SCHEMBL10000216

CC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2347789 0.91 TSHR (0.32)
Tert-Butanol SCHEMBL2149847 0.86 THRB (0.35)
SCHEMBL758893 0.85 ALDH1A1 (0.35)
SCHEMBL5427 0.85 ALDH1A1 (0.35)
SCHEMBL17742796 0.83
Water SCHEMBL28635166 0.82 ALDH1A1 (0.33)
Bromide SCHEMBL28542014 0.82 ALDH1A1 (0.33)
SCHEMBL22689331 0.82 ALDH1A1 (0.33)
Ammonia Solution, Strong SCHEMBL18983394 0.82 ALDH1A1 (0.33)
SCHEMBL9788267 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024073745-A1 INHIBITORS OF EGFR OR HER2 AND METHODS OF USE ARBELLA THERAPEUTICS, LLC (US) 2024-04-04 WO disclosed
US-20230128167-A1 OLIGOPEPTIDE LINKER INTERMEDIATE AND PREPARATION METHOD THEREOF MABPLEX INTERNATIONAL, LTD. (CN) 2023-04-27 US disclosed
EP-4129978-A1 NANOPARTICLES COMPRISING DRUG DIMERS, AND USE THEREOF Therabest Co., Ltd. (KR) 2023-02-08 EP disclosed
US-20210403718-A1 Modified Indigo Compounds and Methods of Dyeing a Substrate Using a Modified Indigo Compound THE H.D. LEE COMPANY, INC. (US) 2021-12-30 US disclosed
EP-2864289-B1 CYCLOPROPANECARBOXAMIDO-SUBSTITUTED AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS CB THERAPEUTICS INC (KY) 2018-04-11 EP disclosed
US-20180000788-A1 CYCLIC UREAS AS INHIBITORS OF ROCK BRISTOL MYERS SQUIBB CO (US) 2018-01-04 US disclosed
EP-3066088-B1 CYCLIC CARBONATE AZIDE AKZO NOBEL CHEMICALS INT BV (NL) 2017-12-06 EP disclosed
US-20160297834-A1 ACC INHIBITORS AND USES THEREOF GILEAD APOLLO, LLC 2016-10-13 US disclosed
US-20160159791-A1 COMPOUNDS AS MODULATORS OF RORC BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2016-06-09 US disclosed
US-8969557-B2 ACC inhibitors and uses thereof Nimbus Apollo, Inc. (US) 2015-03-03 US disclosed
US-20140343053-A1 TRIAZOLOPYRIDINONE PDE10 INHIBITORS MERCK SHARPE & DOHME CORP. (US) 2014-11-20 US disclosed
US-20130123231-A1 ACC INHIBITORS AND USES THEREOF Nimbus Apollo, Inc. (US) 2013-05-16 US disclosed
US-20120108809-A1 PROCESS FOR PREPARATION OF EFAVIRENZ LUPIN LIMITED (IN) 2012-05-03 US disclosed
EP-2223952-A1 Adhesive formulations Tyco Healthcare Group LP (US) 2010-09-01 EP disclosed