SCHEMBL10000577

SCHEMBL10000577

Cc1c2c(cc3ccccc13)Cc1cc(-c3ccccc3)cnc1-2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDGFRB P09619 3/20 0.39
PDGFRA P16234 3/20 0.39
MET P08581 2/20 0.39
CDK8 P49336 2/20 0.39
CHEK1 O14757 1/20 0.39
AURKA O14965 1/20 0.39
DAPK3 O43293 1/20 0.39
PRKD3 O94806 1/20 0.39
MAP4K4 O95819 1/20 0.39
ABL1 P00519 1/20 0.39
NTRK1 P04629 1/20 0.39
CSF1R P07333 1/20 0.39
RET P07949 1/20 0.39
PIM1 P11309 1/20 0.39
FGFR1 P11362 1/20 0.39
FLT1 P17948 1/20 0.39
LTK P29376 1/20 0.39
GRK5 P34947 1/20 0.39
KDR P35968 1/20 0.39
MAP2K2 P36507 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10028260 0.84 CTDSP1 (0.41) PDGFRBPDGFRAMETCDK8CHEK1
SCHEMBL10000565 0.79 CYP2A6 (0.36) KDM4ECTDSP1TDP1AKT1TSHR
SCHEMBL10000572 0.76 MAPT (0.54) KDM4ETDP1MEN1NPC1TP53
SCHEMBL10000576 0.73 PSMB5 (0.36) PDGFRBPDGFRACDK8KDRFLT3
SCHEMBL10000578 0.73 CA12 (0.41) PDGFRBPDGFRAMETCDK8CHEK1
SCHEMBL10000593 0.69 CA12 (0.43) KDRGSK3AGSK3BCDK9KDM4E
SCHEMBL10000598 0.68 CYP2A6 (0.39) KDM4ENPC1
SCHEMBL12145842 0.67 NPC1 (0.45) NTRK1NTRK3KDM4ECTDSP1TDP1
SCHEMBL10000579 0.67 CAMKK2 (0.43) KDM4EPARP1MEN1TSHRKMT2A
SCHEMBL10205844 0.66 PSMB5 (0.51) PDGFRBPDGFRAMETCDK8CHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150340628-A1 METAL COMPLEX COMPOUND AND ORGANIC LIGHT EMITTING DIODE DEVICE INCLUDING THE SAME SAMSUNG DISPLAY CO LTD (KR) 2015-11-26 US disclosed
US-9096529-B2 Metal complex compound and organic light emitting diode device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2015-08-04 US disclosed
US-20120012824-A1 METAL COMPLEX COMPOUND AND ORGANIC LIGHT EMITTING DIODE DEVICE INCLUDING THE SAME SAMSUNG MOBILE DISPLAY CO., LTD. (KR) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150340628-A1 METAL COMPLEX COMPOUND AND ORGANIC LIGHT EMITTING DIODE DEVICE INCLUDING THE SAME AP1M1, MT-CO1, AP2M1 PDGFRB 4692/4885PDGFRA 4365/4885MET 3620/4885
US-20120012824-A1 METAL COMPLEX COMPOUND AND ORGANIC LIGHT EMITTING DIODE DEVICE INCLUDING THE SAME AP1M1, MT-CO1, AP2M1 PDGFRB 4692/4885PDGFRA 4365/4885MET 3620/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.