SCHEMBL1000348

SCHEMBL1000348

Cc1ccc2cc(C(=O)Cl)ccc2n1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.53
NPC1 O15118 5/20 0.50
RAB9A P51151 5/20 0.50
POLB P06746 2/20 0.50
KDM4E B2RXH2 2/20 0.50
LMNA P02545 1/20 0.50
CASP6 P55212 1/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
KDM2B Q8NHM5 1/20 0.44
VNN1 O95497 1/20 0.43
PIR O00625 4/20 0.42
HSF1 Q00613 3/20 0.42
BRAF P15056 1/20 0.42
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30464299 0.84 TDP1 (0.58) CYP1A2NPC1RAB9APOLBKDM4E
SCHEMBL5095477 0.84 NPC1 (0.55) CYP1A2NPC1RAB9APOLBKDM4E
SCHEMBL999160 0.84 TDP1 (0.58) CYP1A2NPC1RAB9APOLBKDM4E
SCHEMBL31201668 0.84 NPC1 (0.55) CYP1A2NPC1RAB9APOLBKDM4E
SCHEMBL15286803 0.82 POLB (0.55) CYP1A2NPC1RAB9APOLBKDM4E
Hydrochloric Acid SCHEMBL16621042 0.82 TDP1 (0.56) CYP1A2NPC1RAB9APOLBKDM4E
Hydrochloric Acid SCHEMBL1000350 0.82 TDP1 (0.56) CYP1A2NPC1RAB9APOLBKDM4E
SCHEMBL30163484 0.82 POLB (0.55) CYP1A2NPC1RAB9APOLBKDM4E
SCHEMBL22233920 0.81 NPC1 (0.49) CYP1A2NPC1RAB9APOLBKDM4E
SCHEMBL997513 0.80 HPGD (0.41) NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2456759-B1 PESTICIDAL CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2017-04-19 EP disclosed
US-8822691-B2 Pesticidal carboxamides BAYER CROPSCIENCE AG (DE) 2014-09-02 US disclosed
US-20120277185-A1 Pesticidal Carboxamides BAYER CROPSCIENDE AG (DE) 2012-11-01 US disclosed
EP-2456759-A2 PESTICIDAL CARBOXAMIDES Bayer CropScience AG (DE) 2012-05-30 EP disclosed
WO-2011009540-A2 PESTICIDAL CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2011-01-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120277185-A1 Pesticidal Carboxamides DDT, ACHE, AADAC CYP1A2 309/4885NPC1 4669/4885RAB9A 2235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.