Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10004790 | 1.00 | NPC1 (0.48) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL10004460 | 0.93 | TMPRSS2 (0.41) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL10004457 | 0.93 | TMPRSS2 (0.41) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL1188342 | 0.92 | DGAT1 (0.50) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL1188339 | 0.92 | DGAT1 (0.50) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL1187906 | 0.90 | SYK (0.40) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL1187908 | 0.90 | SYK (0.40) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL13009363 | 0.90 | SYK (0.40) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL1188081 | 0.90 | NPC1 (0.48) | NPC1RAB9ACASP3SENP7DGAT1 | |
| SCHEMBL1187108 | 0.90 | NPC1 (0.48) | NPC1RAB9ACASP3SENP7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202847-A1 | Novel Tetrahydroisoquinoline Compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-09 | — | — | US | claimed |
| EP-2471777-A1 | NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS | Daiichi Sankyo Company, Limited (JP) | 2012-07-04 | — | — | EP | claimed |
| US-20120202847-A1 | Novel Tetrahydroisoquinoline Compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-09 | — | — | US | disclosed |
| US-20120202847-A1 | Novel Tetrahydroisoquinoline Compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-08-09 | — | — | US | disclosed |
| EP-2471777-A1 | NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS | Daiichi Sankyo Company, Limited (JP) | 2012-07-04 | — | — | EP | disclosed |
| WO-2011024932-A1 | NOVEL TETRAHYDROISOQUINOLINE COMPOUNDS | 第一三共株式会社 (JP) | 2011-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202847-A1 | Novel Tetrahydroisoquinoline Compounds | DGAT2, DGAT1, DLAT | NPC1 311/4885RAB9A 1014/4885CASP3 2310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.