Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3548758 | 0.83 | SNCA (0.44) | SNCAAPPCYP3A4ALDH1A1HIF1A | |
| Bromide SCHEMBL5973875 | 0.83 | SNCA (0.46) | SNCAAPPCYP3A4ALDH1A1HIF1A | |
| SCHEMBL1314001 | 0.82 | AGXT (0.42) | CYP3A4ALDH1A1HTTSMN1; SMN2SMYD2 | |
| Bromide SCHEMBL8200978 | 0.81 | SNCA (0.44) | SNCAAPPCYP3A4ALDH1A1HIF1A | |
| SCHEMBL9347235 | 0.79 | ESR1 (0.43) | CYP3A4ALDH1A1HIF1A | |
| SCHEMBL14542685 | 0.79 | AGXT (0.43) | CYP3A4ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL11934179 | 0.79 | TP53 (0.42) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| Bromide SCHEMBL10011566 | 0.79 | TRAP1 (0.33) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| SCHEMBL9347236 | 0.78 | AGXT (0.33) | CYP3A4HTTSMN1; SMN2SMYD2 | |
| SCHEMBL2745018 | 0.78 | PPARG (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10754064-B2 | Second-order nonlinear optical compound and nonlinear optical element comprising the same | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2020-08-25 | — | — | US | disclosed |
| US-20180224577-A1 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2018-08-09 | — | — | US | disclosed |
| US-9977150-B2 | Second-order nonlinear optical compound and nonlinear optical element comprising the same | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2018-05-22 | — | — | US | disclosed |
| US-9488755-B2 | Second-order nonlinear optical compound and nonlinear optical element comprising the same | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2016-11-08 | — | — | US | disclosed |
| US-20160318889-A1 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME | NAT INST INF & COMM TECH (JP) | 2016-11-03 | — | — | US | disclosed |
| US-20150048284-A1 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME | NAT INST INF & COMM TECH (JP) | 2015-02-19 | — | — | US | disclosed |
| US-8846955-B2 | Second-order nonlinear optical compound and nonlinear optical element comprising the same | NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY (JP) | 2014-09-30 | — | — | US | disclosed |
| US-20120172599-A1 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME | SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) | 2012-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318889-A1 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME | OGFOD1, OCIAD2, OCIAD1 | SNCA 612/4885APP 3377/4885CYP3A4 864/4885 |
| US-20150048284-A1 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME | OGFOD1, OCIAD2, OCIAD1 | SNCA 612/4885APP 3377/4885CYP3A4 864/4885 |
| US-10754064-B2 | Second-order nonlinear optical compound and nonlinear optical element comprising the same | OGFOD1, OCIAD2, OCIAD1 | SNCA 612/4885APP 3377/4885CYP3A4 864/4885 |
| US-20180224577-A1 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME | OGFOD1, OCIAD2, OCIAD1 | SNCA 612/4885APP 3377/4885CYP3A4 864/4885 |
| US-20120172599-A1 | SECOND-ORDER NONLINEAR OPTICAL COMPOUND AND NONLINEAR OPTICAL ELEMENT COMPRISING THE SAME | OGFOD1, OCIAD2, OCIAD1 | SNCA 612/4885APP 3377/4885CYP3A4 864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.