Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 7/20 | 0.42 |
| ▸ | CA2 | P00918 | 7/20 | 0.42 |
| ▸ | CA9 | Q16790 | 6/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10013397 | 0.84 | ALDH1A1 (0.51) | TSHRKDM4EMEN1KMT2A | |
| SCHEMBL1741412 | 0.83 | POLB (0.49) | POLBMAPK1HIF1ATSHRCYP2D6 | |
| SCHEMBL2228729 | 0.83 | POLB (0.49) | POLBMAPK1HIF1ATSHRCYP2D6 | |
| SCHEMBL10013398 | 0.81 | ALDH1A1 (0.53) | POLBHIF1ATSHRHPGDMEN1 | |
| SCHEMBL10013375 | 0.80 | PSMB5 (0.46) | CA12CA2CA9KMT2ACA1 | |
| SCHEMBL6238689 | 0.79 | PDCD1 (0.44) | POLBMAPK1HIF1ATSHRCYP2D6 | |
| SCHEMBL10013396 | 0.79 | MEN1 (0.49) | POLBMAPK1TSHRCYP2D6MAPT | |
| SCHEMBL506861 | 0.79 | TLR2 (0.53) | CA12CA2CA9HPGDMEN1 | |
| SCHEMBL506862 | 0.79 | TLR2 (0.53) | CA12CA2CA9HPGDMEN1 | |
| SCHEMBL13093374 | 0.79 | TSHR (0.44) | POLBMAPK1HIF1ATSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853452-B2 | Compounds, their syntheses, compositions, and methods to treat cancer | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 2014-10-07 | — | — | US | disclosed |
| US-20120027844-A1 | COMPOUNDS, THEIR SYNTHESES, COMPOSITIONS, AND METHODS TO TREAT CANCER | XAVIER UNIVERSITY OF LOUISIANA (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120027844-A1 | COMPOUNDS, THEIR SYNTHESES, COMPOSITIONS, AND METHODS TO TREAT CANCER | SGMS1, PHOSPHO1, MCL1 | POLB 2287/4885MAPK1 4426/4885HIF1A 2468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.