Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | P4HB | P07237 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10015154 | 0.90 | KDM1A (0.59) | CYP19A1KDM1ATDP1POLBCALM1 | |
| SCHEMBL13488704 | 0.86 | KDM1A (0.53) | CYP19A1TRPA1P4HBTRPV1KDM1A | |
| SCHEMBL10015144 | 0.82 | CYP19A1 (0.45) | CYP19A1TRPA1P4HBTRPV1KDM1A | |
| SCHEMBL10015152 | 0.79 | TRPA1 (0.60) | CYP19A1TRPA1P4HBTRPV1KDM1A | |
| SCHEMBL13488682 | 0.77 | KDM1A (0.51) | CYP19A1TRPA1P4HBTRPV1KDM1A | |
| SCHEMBL31233064 | 0.72 | KDM1A (0.81) | CYP19A1TRPA1P4HBTRPV1KDM1A | |
| SCHEMBL2961146 | 0.70 | TRPA1 (0.75) | CYP19A1TRPA1P4HBTRPV1KDM1A | |
| SCHEMBL7030024 | 0.68 | CYP19A1 (0.80) | CYP19A1PTPN1 | |
| SCHEMBL22380698 | 0.67 | SLCO2B1 (0.77) | CYP19A1TRPA1P4HBTRPV1KDM1A | |
| SCHEMBL22261653 | 0.67 | SLCO2B1 (0.77) | CYP19A1TRPA1P4HBTRPV1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207313-B2 | Natural products from Vinca | WILLIAM MARSH RICE UNIVERSITY (US) | 2012-06-26 | — | — | US | disclosed |
| US-20100048494-A1 | Natural Products from Vinca | RICE UNIVERSITY (US) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048494-A1 | Natural Products from Vinca | HIRA, RDX, SLC22A8 | CYP19A1 227/4885TRPA1 4017/4885P4HB 4046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.