Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 10/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 10/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10016125 | 1.00 | TAS1R3 (0.54) | TAS1R3TAS1R2TAS1R1KDM4EALDH1A1 | |
| SCHEMBL13240250 | 1.00 | TAS1R3 (0.54) | TAS1R3TAS1R2TAS1R1KDM4EALDH1A1 | |
| SCHEMBL15069950 | 0.92 | ALDH1A1 (0.58) | TAS1R3TAS1R2TAS1R1KDM4EALDH1A1 | |
| SCHEMBL15069964 | 0.92 | ALDH1A1 (0.58) | TAS1R3TAS1R2TAS1R1KDM4EALDH1A1 | |
| SCHEMBL15069968 | 0.92 | ALDH1A1 (0.58) | TAS1R3TAS1R2TAS1R1KDM4EALDH1A1 | |
| SCHEMBL14194895 | 0.92 | ALDH1A1 (0.58) | TAS1R3TAS1R2TAS1R1KDM4EALDH1A1 | |
| SCHEMBL10016132 | 0.89 | TAS1R3 (0.52) | TAS1R3TAS1R2TAS1R1KDM4EALDH1A1 | |
| SCHEMBL10016130 | 0.89 | TAS1R3 (0.52) | TAS1R3TAS1R2TAS1R1KDM4EALDH1A1 | |
| SCHEMBL108094 | 0.76 | HDAC6 (0.55) | TAS1R3TAS1R2TAS1R1KDM4EGAA | |
| SCHEMBL2601943 | 0.76 | HDAC6 (0.55) | TAS1R3TAS1R2TAS1R1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9399631-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2016-07-26 | — | — | US | disclosed |
| US-20140045931-A1 | POLYPHENOL PROTEASOME INHIBITORS, SYNTHESIS, AND METHODS OF USE | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2014-02-13 | — | — | US | disclosed |
| US-8563607-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120029067-A1 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use | UNIVERSITY OF SOUTH FLORIDA (US) | 2012-02-02 | — | — | US | disclosed |
| US-7767711-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-08-03 | — | — | US | disclosed |
| US-7358383-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2008-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045931-A1 | POLYPHENOL PROTEASOME INHIBITORS, SYNTHESIS, AND METHODS OF USE | PSMC1, PSMB5, PSMC5 | TAS1R3 4317/4885TAS1R2 4468/4885TAS1R1 4297/4885 |
| US-20120029067-A1 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use | PSMC1, PSMB5, PSMC5 | TAS1R3 4317/4885TAS1R2 4468/4885TAS1R1 4297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.