Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CPB1 | P15086 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20404573 | 0.74 | ALDH1A1 (0.55) | ALDH1A1GAAPOLBHTTSMN1; SMN2 | |
| SCHEMBL20393915 | 0.73 | ALDH1A1 (0.63) | ALDH1A1GAAPOLBHTTSMN1; SMN2 | |
| SCHEMBL20249123 | 0.72 | ALDH1A1 (0.45) | ALDH1A1GAAPOLBHTTSMN1; SMN2 | |
| SCHEMBL20249120 | 0.72 | ALDH1A1 (0.45) | ALDH1A1GAAPOLBHTTSMN1; SMN2 | |
| SCHEMBL20388022 | 0.69 | SMN1; SMN2 (0.58) | ALDH1A1GAAPOLBHTTSMN1; SMN2 | |
| SCHEMBL20393943 | 0.69 | ALDH1A1 (0.68) | ALDH1A1GAAPOLBHTTSMN1; SMN2 | |
| SCHEMBL20393922 | 0.69 | ALDH1A1 (0.68) | ALDH1A1GAAPOLBSMN1; SMN2HPGD | |
| SCHEMBL14365916 | 0.68 | ALDH1A1 (0.56) | ALDH1A1GAAPOLBHTTSMN1; SMN2 | |
| SCHEMBL20387957 | 0.67 | ALDH1A1 (0.72) | ALDH1A1GAAPOLBHTTSMN1; SMN2 | |
| SCHEMBL20388024 | 0.67 | ALDH1A1 (0.68) | ALDH1A1GAAPOLBSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163788-B2 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT BONN (DE) | 2012-04-24 | — | — | US | disclosed |
| US-8163788-B2 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT BONN (DE) | 2012-04-24 | — | — | US | disclosed |
| US-20090105286-A1 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT (DE) | 2009-04-23 | — | — | US | disclosed |
| US-20090105286-A1 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAT (DE) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105286-A1 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors | CYTH2, CYTH3, ENTPD5 | ALDH1A1 4265/4885GAA 1613/4885POLB 3390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.