Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.65 |
| ▸ | HTR1A | P08908 | 9/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400205 | 0.83 | DRD2 (0.69) | DRD2SLC6A4HTR1AHTR2AMCHR1 | |
| SCHEMBL252470 | 0.82 | DRD2 (0.66) | DRD2SLC6A4HTR1AHTR2AMCHR1 | |
| SCHEMBL254963 | 0.80 | DRD2 (0.70) | DRD2SLC6A4HTR1AHTR2AMCHR1 | |
| SCHEMBL16712643 | 0.80 | DRD2 (0.62) | DRD2SLC6A4HTR1A | |
| SCHEMBL253667 | 0.79 | DRD2 (0.66) | DRD2SLC6A4HTR1AHTR2AMCHR1 | |
| SCHEMBL3407608 | 0.79 | DRD2 (0.74) | DRD2SLC6A4HTR1AHTR2AMCHR1 | |
| SCHEMBL16702266 | 0.79 | DRD2 (0.61) | DRD2SLC6A4HTR1AHTR2AMCHR1 | |
| SCHEMBL248100 | 0.79 | DRD2 (0.64) | DRD2SLC6A4HTR1AHTR2AMCHR1 | |
| SCHEMBL29785732 | 0.78 | DRD2 (0.54) | DRD2HTR2AHRH1CCR3DRD4 | |
| SCHEMBL14564660 | 0.77 | DRD2 (0.56) | DRD2SLC6A4HTR1AHTR2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101619-B2 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-01-24 | — | — | US | disclosed |
| US-8101619-B2 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-01-24 | — | — | US | disclosed |
| EP-1824479-B1 | PHENYLPIPERAZINE DERIVATIVES WITH A COMBINATION OF PARTIAL DOPAMINE-D2 RECEPTOR AGONISM AND SEROTONIN REUPTAKE INHIBITION | SOLVAY PHARM BV (NL) | 2008-11-05 | — | — | EP | disclosed |