Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GPX4 | P36969 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10019242 | 0.88 | KCNN4 (0.41) | KCNN4KCNA5GSK3BKDM4EGABRA1 | |
| SCHEMBL14034672 | 0.81 | ALDH1A1 (0.54) | KDM4EALDH1A1RAB9ANPC1TP53 | |
| SCHEMBL5036230 | 0.80 | KDM4E (0.51) | KCNN4KCNA5GSK3BKDM4EGABRA1 | |
| SCHEMBL5885580 | 0.77 | KCNN4 (0.40) | KCNN4KCNA5GSK3BKDM4EGABRA1 | |
| SCHEMBL10019243 | 0.75 | KCNN4 (0.37) | KCNN4KCNA5KDM4EGABRA1GABRG2 | |
| SCHEMBL14229160 | 0.74 | TP53 (0.52) | KCNN4KCNA5ALDH1A1RAB9ANPC1 | |
| SCHEMBL5886035 | 0.73 | KDM4E (0.39) | KCNN4KCNA5GSK3BKDM4EGABRA1 | |
| SCHEMBL17265581 | 0.72 | MAPK14 (0.45) | KCNN4KCNA5GSK3BALDH1A1FFAR1 | |
| SCHEMBL29603007 | 0.72 | KCNN4 (0.43) | KCNN4KCNA5GSK3BMAPK1ALDH1A1 | |
| SCHEMBL28785615 | 0.72 | KCNN4 (0.43) | KCNN4KCNA5GSK3BMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101619-B2 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-01-24 | — | — | US | disclosed |
| US-8101619-B2 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-01-24 | — | — | US | disclosed |
| EP-1827427-B1 | ARYLOXYETHYLAMINE DERIVATIVES WITH A COMBINATION OF PARTIAL DOPAMINE-D2 RECEPTOR AGONISM AND SEROTONIN REUPTAKE INHIBITION | SOLVAY PHARM BV (NL) | 2008-07-23 | — | — | EP | disclosed |