Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.33 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.33 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10019242 | 0.76 | KCNN4 (0.41) | KCNN4KCNA5KCNA3KDM4EGABRA1 | |
| SCHEMBL10019239 | 0.75 | KCNN4 (0.41) | KCNN4KCNA5KDM4EGABRA1GABRG2 | |
| SCHEMBL10019241 | 0.73 | ICMT (0.41) | KCNA5BACE1ACHEMAPK1 | |
| SCHEMBL30945338 | 0.72 | HTR7 (0.43) | MTNR1AMTNR1B | |
| SCHEMBL20954508 | 0.72 | HTR7 (0.43) | MTNR1AMTNR1B | |
| SCHEMBL16560398 | 0.71 | LTA4H (0.43) | SMYD2KDM4EMEN1KMT2A | |
| SCHEMBL17755998 | 0.70 | SMYD2 (0.42) | SMYD2PPARA | |
| SCHEMBL16560397 | 0.69 | LTA4H (0.52) | MEN1KMT2A | |
| SCHEMBL5036230 | 0.69 | KDM4E (0.51) | KCNN4KCNA5GRM5KDM4EGABRA1 | |
| SCHEMBL25331014 | 0.69 | TDP1 (0.37) | SMYD2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101619-B2 | Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition | SOLVAY PHARMACEUTICALS B.V. (NL) | 2012-01-24 | — | — | US | disclosed |