Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 12/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | GLA | P06280 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10019487 | 0.89 | NPC1 (0.49) | NPC1SMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL867783 | 0.88 | NPC1 (0.41) | NPC1SMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL866806 | 0.86 | NPC1 (0.40) | NPC1SMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL867888 | 0.84 | ATP4A (0.41) | NPC1SMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL868332 | 0.84 | KMT2A (0.46) | NPC1SMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL867939 | 0.83 | ATP4A (0.44) | NPC1SMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL867655 | 0.82 | TSHR (0.52) | NPC1SMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL30171250 | 0.81 | MAPT (0.56) | NPC1SMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL28948316 | 0.81 | MAPT (0.56) | NPC1SMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL867286 | 0.80 | TSHR (0.42) | NPC1SMN1; SMN2RAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8377698-B2 | 8-hydroxyquinoline acetamide compound, 8-hydroxy quinoline thioamide compound and use thereof | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2013-02-19 | — | — | US | disclosed |
| US-20120077275-A1 | NOVEL 8-HYDROXYQUINOLINE ACETAMIDE COMPOUND, 8-HYDROXY QUINOLINE THIOAMIDE COMPOUND AND USE THEREOF | SAMSUNG ELECTRONICS CO.. LTD. (KR) | 2012-03-29 | — | — | US | disclosed |