Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 11/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.39 |
| ▸ | GLA | P06280 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL866806 | 0.90 | NPC1 (0.40) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10019488 | 0.88 | NPC1 (0.44) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL867888 | 0.88 | ATP4A (0.41) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL868332 | 0.87 | KMT2A (0.46) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL867939 | 0.86 | ATP4A (0.44) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10019487 | 0.84 | NPC1 (0.49) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL867655 | 0.81 | TSHR (0.52) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL867286 | 0.80 | TSHR (0.42) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL30171250 | 0.79 | MAPT (0.56) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL28948316 | 0.79 | MAPT (0.56) | NPC1ALDH1A1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058074-B2 | 8-hydroxyquinoline acetamide compound, 8-hydroxy quinoline thioamide compound and use thereof | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2011-11-15 | — | — | US | claimed |
| US-20080044913-A1 | NOVEL 8-HYDROXYQUINOLINE ACETAMIDE COMPOUND, 8-HYDROXY QUINOLINE THIOAMIDE COMPOUND AND USE THEREOF | CHUNG-ANG UNIVERSITY INUDSTRY-ACADEMY COOPERATION FOUNDATION (KR) | 2008-02-21 | — | — | US | claimed |
| US-8377698-B2 | 8-hydroxyquinoline acetamide compound, 8-hydroxy quinoline thioamide compound and use thereof | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2013-02-19 | — | — | US | disclosed |
| US-20120077275-A1 | NOVEL 8-HYDROXYQUINOLINE ACETAMIDE COMPOUND, 8-HYDROXY QUINOLINE THIOAMIDE COMPOUND AND USE THEREOF | SAMSUNG ELECTRONICS CO.. LTD. (KR) | 2012-03-29 | — | — | US | disclosed |
| US-8058074-B2 | 8-hydroxyquinoline acetamide compound, 8-hydroxy quinoline thioamide compound and use thereof | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2011-11-15 | — | — | US | disclosed |
| US-20080044913-A1 | NOVEL 8-HYDROXYQUINOLINE ACETAMIDE COMPOUND, 8-HYDROXY QUINOLINE THIOAMIDE COMPOUND AND USE THEREOF | CHUNG-ANG UNIVERSITY INUDSTRY-ACADEMY COOPERATION FOUNDATION (KR) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044913-A1 | NOVEL 8-HYDROXYQUINOLINE ACETAMIDE COMPOUND, 8-HYDROXY QUINOLINE THIOAMIDE COMPOUND AND USE THEREOF | TST, TMT1A, HDHD5 | NPC1 4221/4885ALDH1A1 787/4885RAB9A 2107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.