Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.72 |
| ▸ | RAB9A | P51151 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.61 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.57 |
| ▸ | LDHA | P00338 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15887355 | 0.89 | DYRK1A (0.64) | NPC1RAB9AMEN1KMT2ADYRK1A | |
| SCHEMBL12512734 | 0.89 | DYRK1A (0.68) | NPC1RAB9AMEN1KMT2ADYRK1A | |
| SCHEMBL4132162 | 0.88 | DYRK1A (0.63) | NPC1RAB9AMEN1KMT2ADYRK1A | |
| SCHEMBL20049820 | 0.86 | RAB9A (0.69) | NPC1RAB9AMEN1KMT2ADYRK1A | |
| SCHEMBL24133141 | 0.85 | RAB9A (0.67) | NPC1RAB9AMEN1KMT2ADYRK1A | |
| SCHEMBL4294190 | 0.82 | RAB9A (0.66) | NPC1RAB9AMEN1KMT2ADYRK1A | |
| SCHEMBL13766450 | 0.82 | DYRK1A (0.70) | NPC1RAB9AMEN1KMT2ADYRK1A | |
| SCHEMBL10170616 | 0.81 | DYRK1A (1.00) | NPC1RAB9ADYRK1ACYP1A2CYP3A4 | |
| SCHEMBL2175580 | 0.81 | DYRK1A (1.00) | NPC1RAB9AMEN1KMT2ADYRK1A | |
| SCHEMBL13201319 | 0.80 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2ADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
| US-20120165322-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165322-A1 | RHO KINASE INHIBITORS | ROCK1, ROCK2, RHOA | NPC1 600/4885RAB9A 100/4885MEN1 1338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.