Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 2/20 | 0.46 |
| ▸ | KLK1 | P06870 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10174227 | 0.82 | ALDH1A1 (0.56) | GAAALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL13898612 | 0.82 | ALDH1A1 (0.53) | GAAALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL2740732 | 0.81 | CA12 (0.56) | GAAALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL19618949 | 0.81 | CA12 (0.56) | GAAALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL13265140 | 0.81 | HDAC8 (0.49) | GAAALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL15809416 | 0.78 | HSP90AB1 (0.51) | GAAALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL12926115 | 0.76 | NR1I2 (0.45) | MPOHDAC8HTTPLGKLK1 | |
| SCHEMBL11315020 | 0.76 | GAA (0.54) | GAAALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL23734496 | 0.76 | MPO (0.44) | GAAALDH1A1LMNAMPOHDAC8 | |
| SCHEMBL13656129 | 0.75 | HDAC6 (0.71) | ALDH1A1TP53HDAC8HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120027685-A1 | DETERMINING THE CAPABILITY OF A TEST COMPOUND TO AFFECT SOLID TUMOR STEM CELLS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-02-02 | — | — | US | disclosed |