Telomestatin

Telomestatin

SCHEMBL10025441

Cc1oc2nc1-c1nc(co1)-c1nc(co1)-c1nc(co1)-c1nc(co1)-c1nc(co1)C1=NC(CS1)c1nc-2c(C)o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TERT O14746 3/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13954197 0.84 TERT (0.71) TERT
SCHEMBL13587915 0.78 TERT (0.64) TERT
SCHEMBL805247 0.74 TERT (0.56) TERT
SCHEMBL14307852 0.67 TERT (0.50) TERT
SCHEMBL800451 0.56 TERT (0.37) TERT
SCHEMBL12299121 0.46
SCHEMBL11957235 0.45 CCR1 (0.59)
SCHEMBL2089931 0.44 KDM4E (0.56)
SCHEMBL24921366 0.43 PTGDR (0.39)
SCHEMBL1200783 0.42 CCR1 (0.44)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250283075-A1 COMPOSITIONS FOR TARGETING FLI-1 AND METHODS OF USE THEREOF MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) 2025-09-11 US disclosed
EP-4543854-A1 STAT DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-04-30 EP disclosed
CN-115490708-B Sulfonamide macrocyclic derivative, preparation method and application thereof 苏州亚盛药业有限公司 2025-01-24 CN disclosed
WO-2023250058-A1 STAT DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-12-28 WO disclosed
CN-116964061-A Tricyclic pyrimidines as cyclin dependent kinase 7 (CDK 7) inhibitors 詹森药业有限公司 2023-10-27 CN disclosed
CN-116234931-A Bicyclic conjugates with specificity for NECTIN-4 and uses thereof 拜斯科技术开发有限公司 2023-06-06 CN disclosed
EP-4161575-A1 CRYSTALLINE FORMS OF IRAK DEGRADERS Kymera Therapeutics, Inc. (US) 2023-04-12 EP disclosed
WO-2023028605-A1 COMPOSITIONS FOR TARGETING FLI-1 AND METHODS OF USE THEREOF MUSC FOUNDATION FOR RESEARCH DEVELOPMENT D/B/A ZUCKER INSTITUTE FOR INNOVATION COMMERCIALIZATION (US) 2023-03-02 WO disclosed
CN-115490708-A Sulfonamide macrocyclic derivatives, and preparation method and application thereof 苏州亚盛药业有限公司 2022-12-20 CN disclosed
US-20220380362-A1 PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF JAPAN TOBACCO INC. (JP) 2022-12-01 US disclosed
US-20120046234-A1 THERAPEUTIC COMPOUNDS NIH - DEITR 2012-02-23 US disclosed
US-20110230531-A1 THERAPEUTIC COMPOUNDS NIH - DEITR 2011-09-22 US disclosed
US-20110230531-A1 THERAPEUTIC COMPOUNDS NIH - DEITR 2011-09-22 US disclosed
US-20100249175-A1 Dicationic compounds which selectively recognize G-quadruplex DNA GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2010-09-30 US disclosed
US-20100249175-A1 Dicationic compounds which selectively recognize G-quadruplex DNA GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. 2010-09-30 US disclosed
US-7470714-B2 GM-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent SOSEI CO., LTD. (JP) 2008-12-30 US disclosed
US-7470714-B2 GM-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent SOSEI CO., LTD. (JP) 2008-12-30 US disclosed
EP-1792613-A2 Dicationic compounds which selectively recognize G-quadruplex DNA UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2007-06-06 EP disclosed
US-7192763-B2 Streptomyces anulatus microorganism and a process for producing the substance GM-95 SOSEI CO., LTD. (JP) 2007-03-20 US disclosed
US-7192763-B2 Streptomyces anulatus microorganism and a process for producing the substance GM-95 SOSEI CO., LTD. (JP) 2007-03-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100249175-A1 Dicationic compounds which selectively recognize G-quadruplex DNA DDB1, DNA2, SSBP1 TERT 543/4885
US-20220380362-A1 PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF TYMP, TYMS, DPYD TERT 134/4885
US-20250283075-A1 COMPOSITIONS FOR TARGETING FLI-1 AND METHODS OF USE THEREOF FLI1, GAP43, FLNA TERT 2440/4885
US-20120046234-A1 THERAPEUTIC COMPOUNDS MKI67, MCL1, TP53 TERT 281/4885
US-20110230531-A1 THERAPEUTIC COMPOUNDS MCL1, MKI67, NCL TERT 72/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.