Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.46 |
| ▸ | EED | O75530 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10025568 | 0.76 | ALDH1A1 (0.40) | ALDH1A1CYP1A2DPP4KDM4ELMNA | |
| SCHEMBL21315670 | 0.69 | MTNR1A (0.68) | MTNR1AMTNR1BHTR2AHTR2CHTR2B | |
| SCHEMBL19776415 | 0.68 | ALDH1A1 (0.40) | MTNR1AMTNR1BALDH1A1CYP1A2 | |
| SCHEMBL21315651 | 0.67 | MTNR1A (0.69) | MTNR1AMTNR1BEEDSUZ12EZH2 | |
| SCHEMBL2733814 | 0.67 | PARP1 (0.41) | MTNR1AMTNR1BEEDSUZ12EZH2 | |
| SCHEMBL19775896 | 0.67 | MAPT (0.47) | MTNR1AMTNR1BEEDALDH1A1CYP1A2 | |
| SCHEMBL12438628 | 0.67 | MTNR1A (0.40) | MTNR1AMTNR1BEEDALDH1A1CYP1A2 | |
| SCHEMBL18133624 | 0.66 | DPP4 (0.42) | ALDH1A1DPP4KDM4ELMNAMAPT | |
| SCHEMBL13541836 | 0.65 | DPP4 (0.41) | ALDH1A1DPP4KDM4ELMNAMAPT | |
| SCHEMBL8081108 | 0.63 | MAP3K14 (0.47) | MTNR1AMTNR1BKIF11SLC9A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207173-B2 | Benzimidazoles and analogs thereof as antivirals | ISIS PHARMACEUTICALS, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20100130513-A1 | BENZIMIDAZOLES AND ANALOGS THEREOF AS ANTIVIRALS | ISIS PHARMACEUTICALS, INC. (US) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130513-A1 | BENZIMIDAZOLES AND ANALOGS THEREOF AS ANTIVIRALS | ZC3HAV1, NXF1, ZC3HAV1L | MTNR1A 2498/4885MTNR1B 2737/4885EED 3042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.