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SCHEMBL1002765

SCHEMBL1002765

COC(=O)c1cc2c([nH]1)CCC2Cc1ccc(F)c(Cl)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.36
▸ MAPT P10636 1/20 0.36
▸ CASP3 P42574 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ SENP7 Q9BQF6 1/20 0.36
▸ OPRK1 P41145 2/20 0.35
▸ ALPL P05186 1/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ GRM2 Q14416 1/20 0.35
▸ GRM3 Q14832 1/20 0.35
▸ KCNJ6 P48051 1/20 0.34
▸ KCNJ5 P48544 1/20 0.34
▸ KCNJ3 P48549 1/20 0.34
▸ CCR2 P41597 1/20 0.34
▸ SLC6A2 P23975 2/20 0.34
▸ SLC6A4 P31645 2/20 0.34
▸ SLC6A3 Q01959 2/20 0.34
▸ HDAC3 O15379 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1004434 0.90 TSHR (0.40) MEN1KMT2AALDH1A1SLC6A2SLC6A4
SCHEMBL1003927 0.90 PTGS1 (0.35) MEN1MAPTKMT2AALDH1A1HDAC2
SCHEMBL1004177 0.88 MAPT (0.38) MAPTALDH1A1LMNASLC6A2SLC6A3
SCHEMBL1004610 0.87 GRM2 (0.39) GRM2GRM3HDAC3HDAC1HDAC2
SCHEMBL1004655 0.86 NPC1 (0.37) MEN1MAPTKMT2AALPLSLC6A4
SCHEMBL1005522 0.85 POLB (0.42) MEN1MAPTKMT2AHTTSLC6A2
SCHEMBL1003720 0.84 KMT2A (0.33) MEN1KMT2AALDH1A1LMNAHDAC6
SCHEMBL2074424 0.83 MMP1 (0.41) MEN1MAPTKMT2AALDH1A1LMNA
SCHEMBL1003747 0.83 CA1 (0.44) MEN1KMT2AALDH1A1
SCHEMBL1004248 0.83 NPC1 (0.35) MEN1MAPTKMT2AOPRK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7902252-B2 Inhibitors of D-amino acid oxidase SEPRACOR, INC. (US) 2011-03-08 — — US disclosed
US-7902252-B2 Inhibitors of D-amino acid oxidase SEPRACOR, INC. (US) 2011-03-08 — — US disclosed
US-7902252-B2 Inhibitors of D-amino acid oxidase SEPRACOR, INC. (US) 2011-03-08 — — US disclosed
WO-2011011330-A2 INHIBITORS OF D-AMINO ACID OXIDASE SEPRACOR INC. (US) 2011-01-27 — — WO disclosed
WO-2011011330-A2 INHIBITORS OF D-AMINO ACID OXIDASE SEPRACOR INC. (US) 2011-01-27 — — WO disclosed
US-20100029737-A1 INHIBITORS OF D-AMINO ACID OXIDASE SEPRACOR INC. (US) 2010-02-04 — — US disclosed
US-20100029737-A1 INHIBITORS OF D-AMINO ACID OXIDASE SEPRACOR INC. (US) 2010-02-04 — — US disclosed
US-20100029737-A1 INHIBITORS OF D-AMINO ACID OXIDASE SEPRACOR INC. (US) 2010-02-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029737-A1 INHIBITORS OF D-AMINO ACID OXIDASE DDO, DAO, ACHE MEN1 4856/4885MAPT 444/4885CASP3 3012/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.