Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.58 |
| ▸ | ABCC1 | P33527 | 5/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120567 | 0.86 | REV1 (0.57) | KDM4ETDP1KMT2AREV1MAPT | |
| SCHEMBL5131462 | 0.82 | KDM4E (0.71) | KDM4ETDP1KMT2AREV1MAPT | |
| SCHEMBL5129280 | 0.81 | REV1 (0.66) | KDM4ETDP1KMT2AREV1MAPT | |
| SCHEMBL5130886 | 0.80 | REV1 (0.67) | KDM4ETDP1KMT2AREV1MAPT | |
| SCHEMBL5128393 | 0.79 | REV1 (0.69) | KDM4ETDP1KMT2AREV1MAPT | |
| SCHEMBL10028313 | 0.79 | KDM4E (0.62) | KDM4ETDP1KMT2AREV1MAPT | |
| SCHEMBL5125365 | 0.79 | ABCB1 (0.69) | KDM4ETDP1KMT2AREV1MAPT | |
| SCHEMBL3810641 | 0.78 | KMT2A (0.76) | KDM4ETDP1KMT2AREV1MAPT | |
| SCHEMBL3058994 | 0.78 | REV1 (0.64) | KDM4ETDP1KMT2AREV1MAPT | |
| SCHEMBL3052881 | 0.77 | KDM4E (0.70) | KDM4ETDP1REV1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9402824-B2 | 9,10-α, α-OH-taxane analogs and methods for production thereof | TAPESTRY PHARMACEUTICALS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20150133536-A1 | 9, 10-Alpha, Alpha-OH-Taxane Analogs and Methods for Production Thereof | TAPESTRY PHARMACEUTICALS, INC. (US) | 2015-05-14 | — | — | US | disclosed |
| US-8962870-B2 | 9, 10-α, α-OH-taxane analogs and methods for production thereof | TAPESTRY PHARMACEUTICALS, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-20120077871-A1 | 9, 10-Alpha, Alpha-OH-Taxane Analogs and Methods for Production Thereof | TAPESTRY PHARMACEUTICALS, INC. (US) | 2012-03-29 | — | — | US | disclosed |
| US-20120077871-A1 | 9, 10-Alpha, Alpha-OH-Taxane Analogs and Methods for Production Thereof | TAPESTRY PHARMACEUTICALS, INC. (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077871-A1 | 9, 10-Alpha, Alpha-OH-Taxane Analogs and Methods for Production Thereof | TECR, ADCY9, AKR1C3 | KDM4E 4743/4885TDP1 2434/4885KMT2A 3997/4885 |
| US-20150133536-A1 | 9, 10-Alpha, Alpha-OH-Taxane Analogs and Methods for Production Thereof | TECR, ADCY9, AKR1C3 | KDM4E 4743/4885TDP1 2434/4885KMT2A 3997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.