SCHEMBL10028486

SCHEMBL10028486

CN1c2ccccc2C(=C2Sc3ccccc3S2)c2ccccc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.55
NOX1 Q9Y5S8 4/20 0.42
ADRA2A P08913 3/20 0.42
SLC6A2 P23975 3/20 0.42
SLC6A4 P31645 3/20 0.42
DRD3 P35462 3/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
ADRA2B P18089 1/20 0.42
ADRA2C P18825 1/20 0.42
CHRM3 P20309 1/20 0.42
HTR2C P28335 1/20 0.42
HTR2B P41595 1/20 0.42
MAPT P10636 6/20 0.42
ALDH1A1 P00352 6/20 0.42
HPGD P15428 4/20 0.42
LMNA P02545 3/20 0.41
TDP1 Q9NUW8 2/20 0.41
MAPK1 P28482 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13911453 0.81 ALDH1A1 (0.43) MAOAADRA2ASLC6A2SLC6A4DRD3
SCHEMBL30542242 0.79 TTR (0.54) MAOAADRA2ASLC6A2SLC6A4DRD3
SCHEMBL3797403 0.79 TTR (0.54) MAOAADRA2ASLC6A2SLC6A4DRD3
SCHEMBL25635330 0.73 TTR (0.58) MAOAADRA2ASLC6A2SLC6A4DRD3
SCHEMBL25474107 0.73 MAOA (0.73) MAOANOX1ADRA2ASLC6A2SLC6A4
SCHEMBL231247 0.72 MAOA (1.00) MAOANOX1ADRA2ASLC6A2SLC6A4
SCHEMBL29377505 0.72 MAOA (1.00) MAOANOX1ADRA2ASLC6A2SLC6A4
SCHEMBL2604394 0.71 TTR (0.56) MAOAADRA2ASLC6A2SLC6A4DRD3
SCHEMBL14866160 0.71 MAOA (0.63) MAOANOX1ADRA2ASLC6A2SLC6A4
SCHEMBL9135396 0.68 TTR (0.53) ADRA2ASLC6A2SLC6A4DRD3MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8106203-B2 Assay methods using chemiluminescent detection of peroxidase LUMIGEN, INC. (US) 2012-01-31 US disclosed
US-8106203-B2 Assay methods using chemiluminescent detection of peroxidase LUMIGEN, INC. (US) 2012-01-31 US disclosed
EP-2096110-B1 Acridane-9-dithiocarboxylate derivatives for generating chemiluminescence with a peroxidase LUMIGEN INC (US) 2011-06-22 EP disclosed
US-20090246819-A1 Assay Methods Using Chemiluminescent Detection of Peroxidase LUMIGEN, INC. 2009-10-01 US disclosed
US-20090246819-A1 Assay Methods Using Chemiluminescent Detection of Peroxidase LUMIGEN, INC. 2009-10-01 US disclosed
EP-2096110-A1 Acridane-9-dithiocarboxylate derivatives for generating chemiluminescence with a peroxidase LUMIGEN, INC. (US) 2009-09-02 EP disclosed
US-7560556-B2 Assay methods using chemiluminescent detection of peroxidase LUMIGEN, INC. (US) 2009-07-14 US disclosed
US-7560556-B2 Assay methods using chemiluminescent detection of peroxidase LUMIGEN, INC. (US) 2009-07-14 US disclosed
EP-1456176-B1 IMPROVED COMPOUNDS FOR GENERATING CHEMILUMINESCENCE WITH A PEROXIDASE LUMIGEN INC (US) 2009-03-18 EP disclosed
US-7247726-B2 Compounds for generating chemiluminescence with a peroxidase LUMIGEN, INC. (US) 2007-07-24 US disclosed
US-7247726-B2 Compounds for generating chemiluminescence with a peroxidase LUMIGEN, INC. (US) 2007-07-24 US disclosed