SCHEMBL10028754

SCHEMBL10028754

CCNC(=O)c1cc(Cl)cc(Cl)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 3/20 0.37
CHIA Q9BZP6 1/20 0.37
CARM1 Q86X55 4/20 0.37
TRPV1 Q8NER1 5/20 0.37
STIM1 Q13586 1/20 0.37
ORAI1 Q96D31 1/20 0.37
PDE4B Q07343 1/20 0.36
KLKB1 P03952 1/20 0.36
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.36
CYP3A4 P08684 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL951274 0.90 KLKB1 (0.40) CARM1TRPV1PDE4BKLKB1ALDH1A1
SCHEMBL782241 0.90 CARM1 (0.40) CARM1TRPV1STIM1ORAI1PDE4B
SCHEMBL11893097 0.89 PDE4B (0.42) CARM1TRPV1ORAI1PDE4BKLKB1
SCHEMBL10028758 0.89 KDM4E (0.38) TRPV1PDE4BKLKB1ALDH1A1KDM4E
SCHEMBL14698507 0.88 KLKB1 (0.39) NTRK1CARM1TRPV1ORAI1PDE4B
SCHEMBL10028759 0.88 CHIA (0.40) NTRK1CHIAPDE4BALDH1A1MEN1
SCHEMBL14360671 0.88 KLKB1 (0.37) NTRK1CHIACARM1TRPV1STIM1
SCHEMBL12911614 0.88 PDE4B (0.38) NTRK1CARM1TRPV1PDE4BKLKB1
SCHEMBL782369 0.88 PDE4B (0.37) CARM1TRPV1STIM1ORAI1PDE4B
SCHEMBL15971608 0.88 F10 (0.39) CARM1TRPV1PDE4BKLKB1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1699290-B2 INSECTICIDAL ACTIVE SUBSTANCE COMBINATIONS CONTAINING ANTHRANILIC ACID AMIDES AND AT LEAST ONE OTHER INSECTICIDE BAYER CROPSCIENCE AG (DE) 2015-04-15 EP disclosed
EP-1691608-B2 ACTIVE SUBSTANCE COMBINATION HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES BAYER CROPSCIENCE AG (DE) 2015-04-08 EP disclosed
US-8993483-B2 Combination of active substances with insecticidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 US disclosed
US-8993483-B2 Combination of active substances with insecticidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-03-31 US disclosed
US-8865683-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-10-21 US disclosed
US-8865683-B2 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AG (DE) 2014-10-21 US disclosed
US-8821898-B2 Active compound combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2014-09-02 US disclosed
US-8821898-B2 Active compound combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2014-09-02 US disclosed
US-8778895-B2 Active agent combinations with insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-15 US disclosed
US-8778895-B2 Active agent combinations with insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-15 US disclosed
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-03-20 US disclosed
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-03-20 US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 US disclosed
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-11-22 US disclosed
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-11-22 US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142327-A1 Active compound combinations having insecticidal properties ACHE, ANTXR2, NANP NTRK1 4461/4885CHIA 513/4885CARM1 1638/4885
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS NTRK1 4548/4885CHIA 63/4885CARM1 3191/4885
US-20080070863-A1 Combination Of Active Substances With Insecticidal Properties AADAC, ANTXR2, ACHE NTRK1 3699/4885CHIA 251/4885CARM1 2430/4885
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties ACHE, CHRM3, CHRNA2 NTRK1 1175/4885CHIA 1378/4885CARM1 781/4885
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS NTRK1 4584/4885CHIA 87/4885CARM1 3175/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.