SCHEMBL10028840

SCHEMBL10028840

Cc1ccc(-c2cn(-c3ccc(C)cc3)nc2-c2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.67
MEN1 O00255 2/20 0.62
KMT2A Q03164 2/20 0.62
NPC1 O15118 1/20 0.62
RAB9A P51151 1/20 0.62
CA12 O43570 2/20 0.59
CA9 Q16790 2/20 0.59
CNR1 P21554 2/20 0.56
GPR55 Q9Y2T6 1/20 0.56
KDM5B Q9UGL1 2/20 0.54
BCHE P06276 1/20 0.54
ACHE P22303 1/20 0.54
CCNE1 P24864 1/20 0.53
CDK2 P24941 1/20 0.53
LMNA P02545 3/20 0.51
ALDH1A1 P00352 3/20 0.51
KDM4E B2RXH2 3/20 0.51
MAPT P10636 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51
HTT P42858 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13890467 0.95 MEN1 (0.68) PTGS2MEN1KMT2ANPC1RAB9A
SCHEMBL7915220 0.86 PTGS2 (0.66) PTGS2MEN1KMT2ANPC1RAB9A
SCHEMBL4193436 0.86 PTGS2 (0.58) PTGS2MEN1KMT2ANPC1RAB9A
SCHEMBL4186718 0.86 RAB9A (0.65) PTGS2MEN1KMT2ANPC1RAB9A
Ammonia Solution, Strong SCHEMBL27671233 0.84 PTGS2 (0.64) PTGS2MEN1KMT2ANPC1RAB9A
SCHEMBL13890469 0.83 CNR1 (0.61) PTGS2MEN1KMT2ANPC1RAB9A
SCHEMBL4184447 0.82 PTGS2 (0.65) PTGS2MEN1KMT2ANPC1RAB9A
SCHEMBL28718188 0.82 PTGS2 (0.64) PTGS2CA12CA9CNR1GPR55
SCHEMBL28711288 0.82 MEN1 (0.60) PTGS2MEN1KMT2ANPC1RAB9A
SCHEMBL28709958 0.82 PTGS2 (0.64) PTGS2MEN1KMT2ACA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8541557-B2 Azo compound and method of preparing the azo compound RICOH COMPANY, LTD. (JP) 2013-09-24 US disclosed
US-20120253025-A1 AZO COMPOUND AND METHOD OF PREPARING THE AZO COMPOUND RICOH COMPANY, LTD. (JP) 2012-10-04 US disclosed
US-8232376-B2 Azo compound and method of preparing the azo compound RICOH COMPANY, LTD. (JP) 2012-07-31 US disclosed
US-8207312-B2 Method of preparing complex-AZO pigment and complex-AZO pigment thereof RICOH COMPANY, LTD. (JP) 2012-06-26 US disclosed
US-8206880-B2 Electrophotographic photoreceptor, and image forming apparatus and process cartridge therefor using the photoreceptor RICOH COMPANY, LTD. (JP) 2012-06-26 US disclosed
US-20100310975-A1 Electrophotographic Photoreceptor, And Image Forming Apparatus And Process Cartridge Therefor Using The Photoreceptor RICOH COMPANY, LTD. (JP) 2010-12-09 US disclosed
US-20100010204-A1 METHOD OF PREPARING COMPLEX-AZO PIGMENT AND COMPLEX-AZO PIGMENT THEREOF RICOH COMPANY, LTD. (JP) 2010-01-14 US disclosed
US-20090005546-A1 AZO COMPOUND AND METHOD OF PREPARING THE AZO COMPOUND RICOH COMPANY, LTD. (JP) 2009-01-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090005546-A1 AZO COMPOUND AND METHOD OF PREPARING THE AZO COMPOUND CRBN, REL, CDKL1 PTGS2 3733/4885MEN1 632/4885KMT2A 891/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.