Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 10/20 | 0.42 |
| ▸ | FLT4 | P35916 | 10/20 | 0.42 |
| ▸ | KDR | P35968 | 10/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | VCP | P55072 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348184 | 0.86 | FLT1 (0.54) | FLT1FLT4KDRALOX5LMNA | |
| SCHEMBL10033772 | 0.83 | DGAT1 (0.44) | FLT1FLT4KDRLMNA | |
| SCHEMBL2339289 | 0.83 | FLT1 (0.50) | FLT1FLT4KDRALOX5 | |
| SCHEMBL10033771 | 0.82 | ALOX5 (0.45) | FLT1FLT4KDRALOX5 | |
| SCHEMBL10033776 | 0.80 | ALOX5 (0.47) | FLT1FLT4KDRALOX5VCP | |
| SCHEMBL10033773 | 0.80 | KIT (0.45) | FLT1FLT4KDRALOX5LMNA | |
| SCHEMBL2828692 | 0.75 | FLT1 (0.49) | FLT1FLT4KDRALOX5LMNA | |
| SCHEMBL543637 | 0.74 | FLT1 (0.44) | FLT1FLT4KDRALOX5TRPV1 | |
| SCHEMBL10033766 | 0.73 | NPC1 (0.50) | FLT1FLT4KDRALOX5LMNA | |
| SCHEMBL5184593 | 0.72 | KDR (0.67) | FLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658659-B2 | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2014-02-25 | — | — | US | disclosed |
| US-20120108616-A1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AB SCIENCE | 2012-05-03 | — | — | US | disclosed |
| US-20080242704-A1 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242704-A1 | Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors | KIT, TYRO3, LCK | FLT1 168/4885FLT4 110/4885KDR 240/4885 |
| US-20120108616-A1 | SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | KIT, FLT3, LTK | FLT1 7/4885FLT4 6/4885KDR 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.