Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | LATS1 | O95835 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10034652 | 1.00 | HTR2C (0.49) | HTR2CHTR2AHTR2BKCNH2PIM1 | |
| SCHEMBL15217043 | 0.85 | HTR2C (0.47) | HTR2CHTR2AHTR2BKCNH2PIM1 | |
| SCHEMBL15219155 | 0.82 | HTR2C (0.48) | HTR2CHTR2AHTR2BKCNH2PIM1 | |
| SCHEMBL21262057 | 0.79 | HTR2C (0.50) | HTR2CHTR2AHTR2BKCNH2PIM1 | |
| SCHEMBL22578950 | 0.79 | HTR2C (0.50) | HTR2CHTR2AHTR2BKCNH2PIM1 | |
| SCHEMBL26669784 | 0.75 | PIM1 (0.45) | HTR2CHTR2AHTR2BKCNH2PIM1 | |
| SCHEMBL15858056 | 0.75 | HTR2C (0.45) | HTR2CHTR2AHTR2BKCNH2PIM1 | |
| SCHEMBL16422691 | 0.75 | HTR3E (0.50) | HTR2CHTR2A | |
| SCHEMBL18291384 | 0.75 | HTR2C (0.44) | HTR2CHTR2AHTR2BKCNH2PIM1 | |
| SCHEMBL6766547 | 0.74 | HTR2C (0.57) | HTR2CHTR2APIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822448-B2 | Pyrazoloquinoline compound | ASTELLAS PHARMA INC. (JP) | 2014-09-02 | — | — | US | disclosed |
| US-8822448-B2 | Pyrazoloquinoline compound | ASTELLAS PHARMA INC. (JP) | 2014-09-02 | — | — | US | disclosed |
| EP-2615089-A1 | PYRAZOLOQUINOLINE COMPOUND | Astellas Pharma Inc. (JP) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033144-A1 | PYRAZOLOQUINOLINE COMPOUND | アステラス製薬株式会社 (JP) | 2012-03-15 | — | — | WO | disclosed |