Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 9/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.51 |
| ▸ | RET | P07949 | 8/20 | 0.51 |
| ▸ | ROS1 | P08922 | 8/20 | 0.51 |
| ▸ | FLT3 | P36888 | 8/20 | 0.51 |
| ▸ | AXL | P30530 | 7/20 | 0.48 |
| ▸ | ETV6 | P41212 | 5/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | BUB1 | O43683 | 1/20 | 0.43 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.43 |
| ▸ | STK16 | O75716 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10036374 | 0.86 | PDE7A (0.45) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10036375 | 0.82 | FLT3 (0.49) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10129512 | 0.73 | EML4 (0.78) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10036191 | 0.73 | SYK (0.44) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10127653 | 0.71 | EML4 (0.56) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10129514 | 0.70 | EML4 (0.77) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10129842 | 0.69 | EML4 (0.88) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10127661 | 0.68 | EML4 (0.60) | EML4ALKRETROS1FLT3 | |
| SCHEMBL282415 | 0.67 | RET (1.00) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10129505 | 0.67 | EML4 (0.77) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012053606-A1 | ARYLAMINOHETEROCYCLIC CARBOXAMIDE COMPOUND | アステラス製薬株式会社 (JP) | 2012-04-26 | — | — | WO | disclosed |