Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 5/20 | 0.38 |
| ▸ | RET | P07949 | 4/20 | 0.38 |
| ▸ | ROS1 | P08922 | 4/20 | 0.38 |
| ▸ | EML4 | Q9HC35 | 3/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 6/20 | 0.38 |
| ▸ | ETV6 | P41212 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10036188 | 0.76 | FLT3 (0.43) | SYKFLT3RETROS1EML4 | |
| SCHEMBL2719063 | 0.75 | SYK (0.58) | SYKZAP70KCNH2MAPK3MAPK1 | |
| SCHEMBL10036189 | 0.73 | EML4 (0.51) | SYKFLT3RETROS1EML4 | |
| SCHEMBL10036375 | 0.72 | FLT3 (0.49) | SYKWEE1FLT3RETROS1 | |
| SCHEMBL10272164 | 0.70 | SYK (0.53) | SYK | |
| SCHEMBL10128186 | 0.69 | CDK9 (0.45) | SYKALK | |
| SCHEMBL2716069 | 0.69 | SYK (0.56) | SYKFLT3RETALKAURKB | |
| SCHEMBL10128611 | 0.69 | EML4 (0.61) | SYKEML4ALKBRD4 | |
| SCHEMBL10129343 | 0.69 | ALK (0.65) | FLT3RETROS1EML4ALK | |
| SCHEMBL10128535 | 0.68 | SYK (0.64) | SYKZAP70RETROS1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012053606-A1 | ARYLAMINOHETEROCYCLIC CARBOXAMIDE COMPOUND | アステラス製薬株式会社 (JP) | 2012-04-26 | — | — | WO | disclosed |