Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 6/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.63 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 2/20 | 0.55 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166048 | 1.00 | CYP1A1 (0.63) | CYP1A1CYP1A2CYP1B1CYP3A4CYP2D6 | |
| SCHEMBL27497512 | 0.83 | CYP1A1 (0.65) | CYP1A1CYP1A2CYP1B1CYP3A4CYP2D6 | |
| SCHEMBL10036802 | 0.83 | CYP1A1 (0.65) | CYP1A1CYP1A2CYP1B1CYP3A4CYP2D6 | |
| SCHEMBL17745504 | 0.81 | CYP1A1 (0.63) | CYP1A1CYP1A2CYP1B1CYP3A4CYP2D6 | |
| SCHEMBL27494751 | 0.81 | CYP1A1 (0.63) | CYP1A1CYP1A2CYP1B1CYP3A4CYP2D6 | |
| SCHEMBL10001058 | 0.81 | CYP1A1 (0.63) | CYP1A1CYP1A2CYP1B1CYP3A4CYP2D6 | |
| SCHEMBL10735166 | 0.81 | CYP1A1 (0.68) | CYP1A1CYP1A2CYP1B1CYP3A4CYP2D6 | |
| SCHEMBL10735172 | 0.81 | CYP1A1 (0.68) | CYP1A1CYP1A2CYP1B1CYP3A4CYP2D6 | |
| SCHEMBL14305651 | 0.81 | MAPT (0.61) | CYP1A1CYP1A2CYP1B1CYP3A4CYP2D6 | |
| SCHEMBL29364482 | 0.81 | HTT (0.65) | CYP1A1CYP1A2CYP1B1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8334381-B2 | Process for the preparation of intermediates useful in the synthesis of imatinib | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2012-12-18 | — | — | US | disclosed |
| US-8168787-B2 | Process for the preparation of imatinib and intermediates thereof | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2012-05-01 | — | — | US | disclosed |
| US-20100234598-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | FALCHI ALESSANDRO | 2010-09-16 | — | — | US | disclosed |
| US-20100076189-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2010-03-25 | — | — | US | disclosed |
| US-3969363-A | CARDIOVASCULAR DISORDERS | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1976-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076189-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | ABL1, PDGFRA, ABL2 | CYP1A1 386/4885CYP1A2 325/4885CYP1B1 152/4885 |
| US-20100234598-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF | ABL1, PDGFRA, ABL2 | CYP1A1 386/4885CYP1A2 325/4885CYP1B1 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.