Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | HTR3A | P46098 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | GHSR | Q92847 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Elfazepam SCHEMBL259108 | 0.89 | OPRK1 (0.74) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Doxefazepam SCHEMBL554909 | 0.85 | OPRK1 (0.57) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Doxefazepam SCHEMBL31128398 | 0.85 | OPRK1 (0.57) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| SCHEMBL11679711 | 0.84 | OPRK1 (0.74) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| SCHEMBL11745535 | 0.83 | OPRK1 (0.72) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| SCHEMBL11578252 | 0.83 | OPRK1 (0.72) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| SCHEMBL11579759 | 0.81 | OPRK1 (0.72) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Cinolazepam SCHEMBL28142897 | 0.80 | OPRK1 (0.50) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| SCHEMBL11577333 | 0.80 | TP53 (0.64) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| SCHEMBL11578948 | 0.80 | OPRK1 (0.71) | OPRK1DRD3HTR1AHTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593104-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | Müller, Prof. Dr., Wolfgang (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2011011692-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | STC.UNM (US) | 2011-01-27 | — | — | WO | disclosed |