Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.41 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14988393 | 0.88 | MAPT (0.42) | MAPTTHRBHPGDLMNASCN9A | |
| SCHEMBL14988394 | 0.88 | SCN9A (0.44) | MAPTTHRBHPGDLMNASCN9A | |
| SCHEMBL14998507 | 0.83 | USP2 (0.47) | MAPTTHRBSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14998310 | 0.82 | KMT2A (0.46) | MAPTSMN1; SMN2ALDH1A1POLBCYP3A4 | |
| SCHEMBL14998644 | 0.79 | CNR2 (0.53) | MAPTTHRBHPGDCNR2ALDH1A1 | |
| SCHEMBL14998263 | 0.74 | TEAD1 (0.45) | MAPTLMNAALDH1A1POLBCYP2C9 | |
| SCHEMBL8721793 | 0.73 | SCN9A (0.55) | MAPTSCN9APOLBLIPEKMT2A | |
| SCHEMBL10036934 | 0.72 | PPP1CA (0.49) | MAPTALDH1A1POLBKMT2A | |
| SCHEMBL14998441 | 0.70 | ALDH1A1 (0.47) | MAPTLMNASCN9AALDH1A1POLB | |
| SCHEMBL15003085 | 0.70 | ALDH1A1 (0.42) | MAPTLMNAALDH1A1POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012014963-A1 | CONDENSED RING PYRIDINE COMPOUND | アステラス製薬株式会社 (JP) | 2012-02-02 | — | — | WO | disclosed |