Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.67 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.56 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | IL18 | Q14116 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23880582 | 0.94 | PTPN11 (0.70) | GPR35PTPN11PTPN1PTPN6 | |
| SCHEMBL3600204 | 0.83 | MAPT (0.61) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL10495628 | 0.82 | PTPN11 (0.74) | GPR35PTPN11MEN1KMT2APTPN1 | |
| SCHEMBL11054945 | 0.81 | MAPT (0.81) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL20941664 | 0.81 | MAPT (0.54) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL11395159 | 0.80 | GPR35 (1.00) | GPR35PTPN11MAPTHTTMEN1 | |
| SCHEMBL13379288 | 0.80 | PTPN11 (0.61) | PTPN11PTPN1PTPN6 | |
| SCHEMBL201980 | 0.79 | RXFP1 (0.57) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL21138401 | 0.79 | MAPT (0.56) | PTPN11MAPTLMNATSHRHTT | |
| SCHEMBL31598551 | 0.79 | MAPT (0.53) | GPR35MAPTLMNATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087889-A2 | DNA METHYLATION INHIBITORS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-06-28 | — | — | WO | disclosed |