SCHEMBL10037345

SCHEMBL10037345

O=C1c2c(-c3ccc(-c4ccccc4)s3)sc(-c3ccc(-c4ccccc4)s3)c2C(=O)C1(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 2/20 0.40
HSD17B2 P37059 2/20 0.40
CYP2E1 P05181 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2A6 P11509 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2B6 P20813 1/20 0.40
CYP2C19 P33261 1/20 0.40
HDAC6 Q9UBN7 1/20 0.38
AR P10275 1/20 0.38
RAB9A P51151 3/20 0.38
MEN1 O00255 1/20 0.38
POLB P06746 1/20 0.38
KMT2A Q03164 1/20 0.38
NQO2 P16083 3/20 0.37
HDAC1 Q13547 1/20 0.37
PTP4A3 O75365 2/20 0.36
PRKDC P78527 1/20 0.36
NPC1 O15118 2/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10037354 0.93 PTP4A3 (0.33) HSD17B1HSD17B2CYP2E1CYP3A4CYP2A6
SCHEMBL10037343 0.84 MAPT (0.38) CYP3A4CYP2C9CYP2C19PTP4A3KDM4E
SCHEMBL10037346 0.78 DPP4 (0.41) CYP3A4CYP2C9CYP2C19RAB9AMEN1
SCHEMBL10037357 0.76 SNCA (0.33) RAB9AMEN1POLBKMT2ANPC1
SCHEMBL10037353 0.76
SCHEMBL12973008 0.75
SCHEMBL10037355 0.73 HDAC6 (0.42) HSD17B1HDAC6RAB9AKMT2ANQO2
SCHEMBL10037342 0.72 MEN1 (0.38) CYP3A4CYP2C9CYP2C19RAB9AMEN1
SCHEMBL12973001 0.71
SCHEMBL10037350 0.71 LMNA (0.44) CYP3A4CYP2A6CYP2C9CYP2C19HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8114956-B2 Polymer having unit obtained by condensation of difluorocyclopentanedione ring and aromatic ring, organic thin film using the same, and organic thin film device SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-14 US disclosed
US-8114956-B2 Polymer having unit obtained by condensation of difluorocyclopentanedione ring and aromatic ring, organic thin film using the same, and organic thin film device SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-14 US disclosed
US-20100084640-A1 POLYMER HAVING UNIT OBTAINED BY CONDENSATION OF DIFLUOROCYCLOPENTANEDIONE RING AND AROMATIC RING, ORGANIC THIN FILM USING THE SAME, AND ORGANIC THIN FILM DEVICE SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2010-04-08 US disclosed
US-20100084640-A1 POLYMER HAVING UNIT OBTAINED BY CONDENSATION OF DIFLUOROCYCLOPENTANEDIONE RING AND AROMATIC RING, ORGANIC THIN FILM USING THE SAME, AND ORGANIC THIN FILM DEVICE SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2010-04-08 US disclosed
EP-2123690-A1 POLYMER HAVING UNIT OBTAINED BY CONDENSATION OF DIFLUOROCYCLOPENTANEDIONE RING AND AROMATIC RING, ORGANIC THIN FILM USING THE SAME, AND ORGANIC THIN FILM DEVICE Sumitomo Chemical Company, Limited (JP) 2009-11-25 EP disclosed