SCHEMBL10037558

SCHEMBL10037558

COC(=O)/C=C\CCCc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR52 Q9Y2T5 10/20 0.50
TRPV1 Q8NER1 1/20 0.49
MAPT P10636 1/20 0.48
TAAR1 Q96RJ0 1/20 0.45
MEN1 O00255 1/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
KMT2A Q03164 1/20 0.45
HDAC3 O15379 1/20 0.44
MAPK1 P28482 1/20 0.44
ADRA1A P35348 1/20 0.44
HDAC4 P56524 1/20 0.44
SLC6A3 Q01959 1/20 0.44
HDAC1 Q13547 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7374431 0.90 GPR52 (0.60) GPR52
SCHEMBL5972763 0.90 GPR52 (0.60) GPR52
SCHEMBL23533372 0.84 GPR52 (0.48) GPR52MAPTTAAR1MEN1ALDH1A1
SCHEMBL29966313 0.84 GPR52 (0.48) GPR52MAPTTAAR1MEN1ALDH1A1
SCHEMBL6819904 0.83 TRPV1 (0.46) GPR52TRPV1MAPTHDAC3MAPK1
SCHEMBL6819901 0.83 TRPV1 (0.46) GPR52TRPV1MAPTHDAC3MAPK1
SCHEMBL5847973 0.81 GPR52 (0.56) GPR52TRPV1MAPTTAAR1ALDH1A1
SCHEMBL5847965 0.81 GPR52 (0.56) GPR52TRPV1MAPTTAAR1ALDH1A1
SCHEMBL9943909 0.81 TRPV1 (0.49) GPR52TRPV1TAAR1ALDH1A1LMNA
SCHEMBL8262659 0.80 MAOB (0.50) GPR52MAPTALDH1A1LMNAAKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8092720-B2 Polymer-supported metal complex catalyst NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2012-01-10 US disclosed
US-8092720-B2 Polymer-supported metal complex catalyst NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2012-01-10 US disclosed
US-20090227743-A1 POLYMER-SUPPORTED METAL COMPLEX CATALYST NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2009-09-10 US disclosed
US-20090227743-A1 POLYMER-SUPPORTED METAL COMPLEX CATALYST NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2009-09-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090227743-A1 POLYMER-SUPPORTED METAL COMPLEX CATALYST PYM1, ARG1, SCO2 GPR52 1632/4885TRPV1 3715/4885MAPT 2790/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.