Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | AR | P10275 | 8/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10054617 | 0.80 | LMNA (0.60) | LMNASMN1; SMN2PRMT5ALDH1A1POLB | |
| SCHEMBL5717747 | 0.78 | LMNA (1.00) | LMNASMN1; SMN2PRMT5ALDH1A1POLB | |
| SCHEMBL30151141 | 0.78 | LMNA (1.00) | LMNASMN1; SMN2PRMT5ALDH1A1POLB | |
| SCHEMBL4931969 | 0.76 | LMNA (0.73) | LMNASMN1; SMN2PRMT5ALDH1A1POLB | |
| SCHEMBL17213420 | 0.75 | SMN1; SMN2 (0.73) | LMNASMN1; SMN2PRMT5ALDH1A1POLB | |
| SCHEMBL4817305 | 0.75 | PRMT5 (0.68) | LMNASMN1; SMN2PRMT5ALDH1A1POLB | |
| SCHEMBL19881880 | 0.74 | LMNA (0.53) | LMNASMN1; SMN2PRMT5ALDH1A1POLB | |
| SCHEMBL9328808 | 0.73 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2PRMT5ALDH1A1POLB | |
| SCHEMBL8559783 | 0.72 | PRMT5 (0.64) | LMNASMN1; SMN2PRMT5ALDH1A1POLB | |
| SCHEMBL23909125 | 0.72 | PRMT5 (0.68) | LMNASMN1; SMN2PRMT5ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019430-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-02-16 | — | — | WO | disclosed |