Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15077743 | 0.90 | SLC6A4 (0.51) | NAAAJAK2JAK1GRIN2BSLC6A2 | |
| SCHEMBL121312 | 0.86 | SLC6A2 (0.51) | NAAAGRIN2BSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21276364 | 0.85 | HRH3 (0.42) | NAAAJAK2JAK1SLC6A2SLC6A4 | |
| SCHEMBL21276164 | 0.81 | SLC6A2 (0.45) | NAAASLC6A2SLC6A4SLC6A3HRH4 | |
| SCHEMBL15077587 | 0.81 | DDB1 (0.45) | NAAAJAK2JAK1GRIN2BSLC6A2 | |
| SCHEMBL28115401 | 0.80 | SLC18A3 (0.50) | NAAAJAK2JAK1GRIN2BSLC18A3 | |
| SCHEMBL7244805 | 0.80 | SLC18A3 (0.46) | GRIN2BSLC6A2SLC6A4SLC6A3SLC18A3 | |
| SCHEMBL28115399 | 0.80 | SLC18A3 (0.50) | NAAAJAK2JAK1GRIN2BSLC18A3 | |
| SCHEMBL27098391 | 0.79 | NAAA (0.50) | NAAAJAK2JAK1GRIN2BSLC6A2 | |
| SCHEMBL28115405 | 0.79 | JAK2 (0.50) | NAAAJAK2JAK1GRIN2BSLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019430-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-02-16 | — | — | WO | disclosed |