Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 9/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.79 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.79 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.79 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.79 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.79 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.79 |
| ▸ | LTA4H | P09960 | 1/20 | 0.69 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366970 | 1.00 | HDAC1 (1.00) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL1366844 | 0.99 | HDAC1 (1.00) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL1365794 | 0.96 | HDAC1 (1.00) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL12727089 | 0.87 | HDAC1 (0.77) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL8294743 | 0.86 | HDAC1 (0.76) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL16128931 | 0.84 | HDAC1 (0.76) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL17404991 | 0.84 | HDAC1 (0.76) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL28975351 | 0.83 | HDAC6 (0.71) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL16127495 | 0.82 | HDAC1 (0.74) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL28215370 | 0.82 | HDAC6 (0.76) | HDAC1HDAC6HDAC10HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | disclosed |
| EP-4171538-B1 | SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | UNIV ILLINOIS (US) | 2026-04-29 | — | — | EP | disclosed |
| US-12522572-B2 | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-01-13 | — | — | US | disclosed |
| EP-3416633-B1 | TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | UNIV ILLINOIS (US) | 2025-07-23 | — | — | EP | disclosed |
| US-20250171433-A1 | A1H-BENZO[C][1,2]THIADIAZINE-2,2-DIOXIDES BEARING HETEROCYCLIC LINKERS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2025-05-29 | — | — | US | disclosed |
| EP-4475845-A1 | A1H-BENZO[C][1,2]THIADIAZINE-2,2-DIOXIDES BEARING HETEROCYCLIC LINKERS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | Georgetown University (US) | 2024-12-18 | — | — | EP | disclosed |
| CN-118973573-A | 1H-benzo [ c ] [1,2] thiadiazine-2, 2-dioxides carrying a heterocyclic linker as selective histone deacetylase 6 inhibitors | 乔治城大学 | 2024-11-15 | — | — | CN | disclosed |
| US-20240343697-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2024-10-17 | — | — | US | disclosed |
| US-12024493-B2 | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2024-07-02 | — | — | US | disclosed |
| US-11739064-B2 | HDAC inhibitors and therapeutic methods using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-08-29 | — | — | US | disclosed |
| US-7842835-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2010-11-30 | — | — | US | disclosed |
| US-20090163543-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | GEORGETOWN UNIVERSITY (US) | 2009-06-25 | — | — | US | disclosed |
| US-7507828-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507828-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507828-B2 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2009-03-24 | — | — | US | disclosed |
| EP-1644323-A4 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | UNIV GEORGETOWN (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1644323-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2006-04-12 | — | — | EP | disclosed |
| US-20050032831-A1 | Histone deacetylase inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY | 2005-02-10 | — | — | US | disclosed |
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | HDAC3, HDAC1, HDAC4 | HDAC1 2/4885HDAC6 10/4885HDAC10 16/4885 |
| US-20250171433-A1 | A1H-BENZO[C][1,2]THIADIAZINE-2,2-DIOXIDES BEARING HETEROCYCLIC LINKERS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS | HDAC1, HDAC6, HDAC11 | HDAC1 1/4885HDAC6 2/4885HDAC10 12/4885 |
| US-20090163543-A1 | Histone Deacetylase Inhibitors and Methods of Use Thereof | HDAC5, HDAC6, HDAC1 | HDAC1 3/4885HDAC6 2/4885HDAC10 11/4885 |
| US-20050032831-A1 | Histone deacetylase inhibitors and methods of use thereof | HDAC5, HDAC6, HDAC1 | HDAC1 3/4885HDAC6 2/4885HDAC10 11/4885 |
| US-12024493-B2 | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors | HDAC1, HDAC7, HDAC5 | HDAC1 1/4885HDAC6 10/4885HDAC10 11/4885 |
| US-11739064-B2 | HDAC inhibitors and therapeutic methods using the same | HDAC1, HDAC9, HDAC8 | HDAC1 1/4885HDAC6 9/4885HDAC10 11/4885 |
| US-20240343697-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | HDAC1, HDAC7, HDAC5 | HDAC1 1/4885HDAC6 10/4885HDAC10 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.