Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.76 |
| ▸ | HDAC10 | Q969S8 | 15/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 12/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.62 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1366970 | 0.86 | HDAC1 (1.00) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL1004150 | 0.86 | HDAC1 (1.00) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL8294740 | 0.86 | HDAC1 (0.56) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL1366844 | 0.85 | HDAC1 (1.00) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL13786320 | 0.83 | HDAC6 (0.76) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL1365794 | 0.82 | HDAC1 (1.00) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL8293929 | 0.81 | HDAC6 (0.60) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL1364734 | 0.77 | HDAC1 (0.71) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL12727089 | 0.73 | HDAC1 (0.77) | HDAC1HDAC6HDAC10HDAC8HDAC2 | |
| SCHEMBL26220123 | 0.71 | HDAC1 (0.48) | HDAC1HDAC6HDAC10HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |