Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10043897 | 0.93 | ALDH1A1 (0.59) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK14 | |
| SCHEMBL10043938 | 0.89 | MAPK14 (0.55) | ALDH1A1RAB9AMAPK14MAPK13RAF1 | |
| SCHEMBL10043944 | 0.87 | SRC (0.41) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK14 | |
| SCHEMBL10043928 | 0.86 | RAB9A (0.45) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK14 | |
| SCHEMBL10043936 | 0.86 | NPC1 (0.48) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK14 | |
| SCHEMBL10043948 | 0.85 | MAPK14 (0.42) | RAB9ANPC1MAPK14MAPK13RAF1 | |
| SCHEMBL10043933 | 0.85 | RAB9A (0.46) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK14 | |
| SCHEMBL501911 | 0.85 | SYK (0.46) | RAB9ANPC1MAPK14MAPK13RAF1 | |
| SCHEMBL10043932 | 0.85 | MAPK14 (0.43) | ALDH1A1RAB9ANPC1MAPK14MAPK13 | |
| SCHEMBL10043870 | 0.84 | RAB9A (0.40) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106068-B2 | Compositions and methods for modulating c-kit and PDGFR receptors | IRM LLC (BM) | 2012-01-31 | — | — | US | disclosed |
| US-20100081656-A1 | COMPOSITIONS AND METHODS FOR MODULATING C-KIT AND PDGFR RECEPTORS | IRM LLC (BM) | 2010-04-01 | — | — | US | disclosed |
| US-7678792-B2 | Compositions and methods for modulating c-kit and PDGFR receptors | IRM LLC (BM) | 2010-03-16 | — | — | US | disclosed |
| US-20080176846-A1 | COMPOSITIONS AND METHODS FOR MODULATING C-KIT AND PDGFR RECEPTORS | IRM LLC (BM) | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176846-A1 | COMPOSITIONS AND METHODS FOR MODULATING C-KIT AND PDGFR RECEPTORS | FYN, FLT3, SRC | ALDH1A1 4274/4885RAB9A 1818/4885NPC1 4095/4885 |
| US-20100081656-A1 | COMPOSITIONS AND METHODS FOR MODULATING C-KIT AND PDGFR RECEPTORS | FYN, FLT3, SRC | ALDH1A1 4274/4885RAB9A 1818/4885NPC1 4095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.