Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10044311 | 0.87 | TDP1 (0.44) | NPC1RAB9ATDP1MEN1KMT2A | |
| SCHEMBL13306004 | 0.81 | POLB (0.36) | NPC1RAB9AKMT2APOLBOPRM1 | |
| SCHEMBL13310715 | 0.80 | TDP1 (0.34) | NPC1RAB9ATDP1MEN1KMT2A | |
| SCHEMBL9858681 | 0.79 | KDM4E (0.43) | TDP1KDM4EKMT2APOLBLMNA | |
| SCHEMBL13306017 | 0.79 | KDM4E (0.38) | NPC1RAB9AKDM4ETP53SMN1; SMN2 | |
| SCHEMBL12337516 | 0.78 | MEN1 (0.36) | NPC1RAB9ATDP1KDM4EMEN1 | |
| Ethane SCHEMBL28508951 | 0.76 | KDM4E (0.41) | TDP1KDM4EKMT2APOLBLMNA | |
| SCHEMBL7765070 | 0.76 | TDP1 (0.62) | NPC1RAB9ATDP1MEN1KMT2A | |
| Carbon Monoxide SCHEMBL10727342 | 0.75 | KDM4E (0.40) | TDP1KDM4EKMT2APOLBLMNA | |
| Cyclohexane SCHEMBL28510424 | 0.75 | KDM4E (0.40) | TDP1KDM4EMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064348-B1 | RECEPTOR FAMILY PROFILING | ENSEMBLE THERAPEUTICS CORP (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20100159455-A1 | RECEPTOR FAMILY PROFILING | ENSEMBLE DISCOVERY | 2010-06-24 | — | — | US | disclosed |
| WO-2008036273-A2 | RECEPTOR FAMILY PROFILING | ENSEMBLE DISCOVERY CORPORATION (US) | 2008-03-27 | — | — | WO | disclosed |