Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Etazolate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.94 |
| ▸ | MAPT | P10636 | 1/20 | 0.94 |
| ▸ | HPGD | P15428 | 1/20 | 0.94 |
| ▸ | BLM | P54132 | 1/20 | 0.94 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.94 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.94 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.64 |
| ▸ | PDE5A | O76074 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etazolate SCHEMBL16703320 | 0.98 | MEN1 (0.98) | MEN1MAPTHPGDBLMPMP22 | |
| Etazolate SCHEMBL123840 | 0.98 | MEN1 (0.98) | MEN1MAPTHPGDBLMPMP22 | |
| Etazolate SCHEMBL29824913 | 0.98 | MEN1 (0.98) | MEN1MAPTHPGDBLMPMP22 | |
| Etazolate SCHEMBL123105 | 0.97 | MEN1 (1.00) | MEN1MAPTHPGDBLMPMP22 | |
| Etazolate SCHEMBL16702579 | 0.96 | MEN1 (0.94) | MEN1MAPTHPGDBLMPMP22 | |
| SCHEMBL2459785 | 0.89 | MEN1 (0.79) | MEN1MAPTHPGDBLMPMP22 | |
| SCHEMBL2459284 | 0.88 | MEN1 (0.79) | MEN1MAPTHPGDBLMPMP22 | |
| SCHEMBL2455499 | 0.86 | MAPT (0.77) | MEN1MAPTHPGDBLMPMP22 | |
| SCHEMBL17017274 | 0.85 | MEN1 (0.76) | MEN1MAPTHPGDBLMPMP22 | |
| SCHEMBL2463203 | 0.85 | MEN1 (0.74) | MEN1MAPTHPGDBLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593104-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | Müller, Prof. Dr., Wolfgang (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2011011692-A2 | METHODS OF TREATING AND PREVENTING/REDUCING THE LIKELIHOOD OF MESIAL TEMPORAL LOBE EPILEPSY (TLE) | STC.UNM (US) | 2011-01-27 | — | — | WO | disclosed |