Etazolate

Etazolate

SCHEMBL123840

CCOC(=O)c1cnc2c(cnn2CC)c1NN=C(C)C

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABRB3

The experimentally established mechanism targets of Etazolate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.98
MAPT P10636 1/20 0.98
HPGD P15428 1/20 0.98
BLM P54132 1/20 0.98
PMP22 Q01453 1/20 0.98
KMT2A Q03164 1/20 0.98
PDE4B Q07343 14/20 0.67
PDE5A O76074 1/20 0.67
ADORA1 P30542 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Etazolate SCHEMBL29824913 1.00 MEN1 (0.98) MEN1MAPTHPGDBLMPMP22
Etazolate SCHEMBL16703320 1.00 MEN1 (0.98) MEN1MAPTHPGDBLMPMP22
Etazolate SCHEMBL123105 0.99 MEN1 (1.00) MEN1MAPTHPGDBLMPMP22
Etazolate SCHEMBL1004450 0.98 MEN1 (0.94) MEN1MAPTHPGDBLMPMP22
Etazolate SCHEMBL16702579 0.98 MEN1 (0.94) MEN1MAPTHPGDBLMPMP22
SCHEMBL2459284 0.89 MEN1 (0.79) MEN1MAPTHPGDBLMPMP22
SCHEMBL2459785 0.89 MEN1 (0.79) MEN1MAPTHPGDBLMPMP22
SCHEMBL2455499 0.88 MAPT (0.77) MEN1MAPTHPGDBLMPMP22
SCHEMBL17017274 0.87 MEN1 (0.76) MEN1MAPTHPGDBLMPMP22
SCHEMBL2463203 0.86 MEN1 (0.74) MEN1MAPTHPGDBLMPMP22

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2109 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240316015-A1 COMPOSITION AND METHOD FOR TREATING TUMORS NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD. (CN) 2024-09-26 US claimed
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol CELLIX BIO PRIVATE LIMITED (IN) 2024-02-20 US claimed
EP-4282413-A1 COMPOSITION AND METHOD FOR TREATING TUMORS NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD. (CN) 2023-11-29 EP claimed
CN-116963773-A Compositions and methods for treating tumors 浙江养生堂天然药物研究所有限公司 2023-10-27 CN claimed
US-20230338345-A1 DRUG COMBINATION AND USE THEREOF NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD. (CN) 2023-10-26 US claimed
EP-3498297-B1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AUTISM STALICLA S A (CH) 2023-06-21 EP claimed
CN-109563089-B Compounds that promote normal processing of APP 巴克老年研究所 2023-06-16 CN claimed
EP-4178948-A2 FUNCTIONALIZED ISONITRILES AND PRODUCTS, PREPARATION AND USES THEREOF Universidade de Santiago de Compostela (ES) 2023-05-17 EP claimed
EP-4140480-A1 DRUG COMBINATION AND USE THEREOF NATURAL MEDICINE INSTITUTE OF ZHEJIANG YANGSHENGTANG CO., LTD. (CN) 2023-03-01 EP claimed
CN-115397411-A Pharmaceutical combination and use thereof 浙江养生堂天然药物研究所有限公司 2022-11-25 CN claimed
EP-1027054-A1 LOCAL ADMINISTRATION OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION Vivus, Inc. (US) 2000-08-16 EP claimed
EP-1012188-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN, Wolf-Georg, Prof. Dr. (DE) 2000-06-28 EP claimed
US-5955459-A Fatty acid-antipsychotic compositions and uses thereof NEUROMEDICA, INC. (US) 1999-09-21 US claimed
WO-1999021558-A2 LOCAL ADMINISTRATION OF PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION VIVUS, INC. (US) 1999-05-06 WO claimed
WO-1999014239-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN WOLF GEORG (DE) 1999-03-25 WO claimed
WO-1997041878-A1 TREATMENT OF MOOD DISORDERS WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-11-13 WO claimed
US-4980379-A ENHANCING EFFICIENCY BY REDUCING ADENOSINE LEVELS THE UNIVERSITY OF VIRGINIA (US) 1990-12-25 US claimed
US-4904472-A Use of adenosine antagonists in the treatment of bradyarrhythmias and mechanical dysfunction associated with cardiopulmonary resuscitation THE UNIVERSITY OF VIRGINIA ALUMNI PATENT FOUNDATION (US) 1990-02-27 US claimed
EP-0174342-B1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES UNIVERSITY OF FLORIDA (US) 1989-12-20 EP claimed
US-4147789-A ANTIPARKINSON AGENTS SANDOZ LTD. (CH) 1979-04-03 US claimed