SCHEMBL1004486

SCHEMBL1004486

NC(=O)N(O)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.48
ALOX5 P09917 1/20 0.45
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 1/20 0.44
HPGD P15428 1/20 0.44
POLB P06746 2/20 0.44
MAPT P10636 2/20 0.44
TSHR P16473 2/20 0.44
HSD17B10 Q99714 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
CYP3A4 P08684 1/20 0.44
PARP1 P09874 1/20 0.44
CYP2C19 P33261 1/20 0.44
RECQL P46063 1/20 0.44
BLM P54132 1/20 0.44
PMP22 Q01453 1/20 0.44
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
ALOX15 P16050 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenol SCHEMBL27390675 0.88 TDP1 (0.42) NPSR1ALOX5ALDH1A1KDM4EHPGD
Thiophene SCHEMBL27623087 0.88 NPSR1 (0.39) NPSR1ALOX5ALDH1A1KDM4EHPGD
SCHEMBL3056260 0.79 NPSR1 (0.52) NPSR1ALDH1A1KDM4EHPGDPOLB
SCHEMBL7886211 0.79 NPSR1 (0.52) NPSR1ALDH1A1KDM4EHPGDPOLB
SCHEMBL29012877 0.78 CA12 (0.47) ALDH1A1HPGDTSHRHSD17B10
SCHEMBL30443817 0.78 CA12 (0.47) ALDH1A1HPGDTSHRHSD17B10
SCHEMBL764342 0.77 NPSR1 (0.50) NPSR1ALOX5ALDH1A1POLBMAPT
SCHEMBL75883 0.77 NPSR1 (0.64) NPSR1ALOX5ALDH1A1HPGDPOLB
SCHEMBL75885 0.77 NPSR1 (0.64) NPSR1ALOX5ALDH1A1HPGDPOLB
SCHEMBL28148401 0.77 NPSR1 (0.64) NPSR1ALOX5ALDH1A1HPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090192220-A1 TREATMENT FOR SOLID TUMORS ORE PHARMACEUTICALS INC. (US) 2009-07-30 US claimed
WO-2009067397-A2 TREATMENT FOR SOLID TUMORS ORE PHARMACEUTICALS INC. (US) 2009-05-28 WO claimed
CN-1192015-C Cell adhesion inhibitors BIOGEN INC (US) 2005-03-09 CN claimed
EP-0022750-B1 1,3,4-THIADIAZOLYLOXY-PHENYL UREAS, THEIR PREPARATION AND HERBICIDES CONTAINING THEM CIBA-GEIGY AG (CH) 1983-05-18 EP claimed
EP-0001556-B1 CYCLOHEXENONE DERIVATIVES, METHOD OF THEIR PREPARATION, HERBICIDAL COMPOSITION CONTAINING THEM AND USE OF SAID CYCLOHEXENONE DERIVATIVES AND HERBICIDAL COMPOSITION, RESPECTIVELY STAUFFER CHEMICAL COMPANY (US) 1981-06-17 EP claimed
EP-0001556-A2 Cyclohexenone derivatives, method of their preparation, herbicidal composition containing them and use of said cyclohexenone derivatives and herbicidal composition, respectively STAUFFER CHEMICAL COMPANY (US) 1979-05-02 EP claimed
JP-7291918-A None JP disclosed
CN-119855820-A Camptothecins compound and its preparation method and use 上海齐鲁制药研究中心有限公司 2025-04-18 CN disclosed
US-20190142940-A1 Method and system for effecting changes in pigmented tissue MOAZED KAMBIZ THOMAS (US) 2019-05-16 US disclosed
CN-106810466-B A method of by aniline and the direct synthesizing Amino-methye methyl formate of urea 陕西煤业化工技术开发中心有限责任公司 2019-05-10 CN disclosed
US-9744237-B2 Method and system for effecting changes in pigmented tissue MOAZED KAMBIZ THOMAS (US) 2017-08-29 US disclosed
CN-107108588-A Condensed-bicyclic (miscellaneous) aromatic compound available for treating cancer 莱德克斯制药公共有限公司 2017-08-29 CN disclosed
US-20120207809-A1 Method and system for effecting changes in pigmented tissue MOAZED KAMBIZ THOMAS (US) 2012-08-16 US disclosed
US-4404356-A USING A 2-HYDROXYPHENYL UREA AS CORING AGENT; STORAGE STABILITY; CASTINGS; MOLDING MATERIALS CIBA-GEIGY CORPORATION (US) 1983-09-13 US disclosed
US-4404356-A USING A 2-HYDROXYPHENYL UREA AS CORING AGENT; STORAGE STABILITY; CASTINGS; MOLDING MATERIALS CIBA-GEIGY CORPORATION (US) 1983-09-13 US disclosed
US-4364769-A PREEMERGENCE, POSTEMERGENCE HERBICIDES CIBA-GEIGY CORPORATION (US) 1982-12-21 US disclosed
US-4294986-A Novel para-phenylalkoxy phenylurea and thiourea compounds and herbicidal use thereof AMERICAN CYANAMID CO. (US) 1981-10-13 US disclosed
US-4289903-A PREEMERGENCE AND POSTEMERGENCE AMERICAN CYANAMID COMPANY (US) 1981-09-15 US disclosed
EP-0017706-A2 N'-Phenyl-N-methylurea derivatives, processes for their preparation and their uses as herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1980-10-29 EP disclosed
US-3951641-A Use of N-(4-isopropoxy-3-chlorophenyl)-N'-methyl-N'-methoxyurea for control of weeds in maize cultures CIBA-GEIGY AG (CH) 1976-04-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090192220-A1 TREATMENT FOR SOLID TUMORS ACAT2, ACAT1, APRT NPSR1 3421/4885ALOX5 1995/4885ALDH1A1 188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.