Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DTYMK | P23919 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.40 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.40 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | PPOX | P50336 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29886620 | 0.90 | ALDH1A1 (0.44) | DTYMKALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1002537 | 0.88 | GPR35 (0.42) | ALDH1A1GPR35TSHRTDP1CYP3A4 | |
| SCHEMBL1038884 | 0.85 | ALDH1A1 (0.43) | DTYMKALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL1039209 | 0.84 | DTYMK (0.46) | DTYMKALDH1A1GPR35TSHRTDP1 | |
| SCHEMBL9898314 | 0.83 | TSHR (0.49) | DTYMKALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL29891185 | 0.83 | ALDH1A1 (0.52) | DTYMKALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL27081346 | 0.83 | ALDH1A1 (0.52) | DTYMKALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30378797 | 0.83 | DTYMK (0.42) | DTYMKALDH1A1CYP1A2CYP2C19TSHR | |
| SCHEMBL1461739 | 0.83 | DTYMK (0.42) | DTYMKALDH1A1CYP1A2CYP2C19TSHR | |
| SCHEMBL2935033 | 0.82 | MAPT (0.41) | DTYMKALDH1A1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3000810-B1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVE AS MEK INHIBITOR | ARRAY BIOPHARMA INC (US) | 2017-07-19 | — | — | EP | disclosed |
| EP-1663210-B1 | BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2017-04-19 | — | — | EP | disclosed |
| EP-3000810-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVE AS MEK INHIBITOR | Array Biopharma, Inc. (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2275102-B1 | N3 alkylated benzimidazole derivatives as MEK inhibitors | ARRAY BIOPHARMA INC (US) | 2015-07-29 | — | — | EP | disclosed |
| US-8580785-B2 | Insecticides | SYNGENTA CROP PROTECTION LLC (US) | 2013-11-12 | — | — | US | disclosed |
| US-8513293-B2 | Methods of treating a hyperproliferative disorder or inhibiting cell growth in a mammal | ARRAY BIOPHARMA INC. (US) | 2013-08-20 | — | — | US | disclosed |
| EP-2130536-B1 | N3 alkylated benzimidazole derivatives as mek inhibitors | ARRAY BIOPHARMA INC (US) | 2013-05-08 | — | — | EP | disclosed |
| EP-2130537-B1 | N3 alkylated benzimidazole derivatives as mek inhibitors | ARRAY BIOPHARMA INC (US) | 2012-11-14 | — | — | EP | disclosed |
| US-20120277277-A1 | Methods of Treating a Hyperproliferative Disorder or Inhibiting Cell Growth in a Mammal | ARRAY BIOPHARMA INC. (US) | 2012-11-01 | — | — | US | disclosed |
| US-8193231-B2 | Compositions comprising N3 alkylated benzimidazole derivatives as MEK inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2012-06-05 | — | — | US | disclosed |
| WO-2003077914-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA, INC (US) | 2003-09-25 | — | — | WO | disclosed |
| US-20020173501-A1 | Antimicrobial quinolones, their compositions and uses | THE PROCTER & GAMBLE COMPANY | 2002-11-21 | — | — | US | disclosed |
| US-6387928-B1 | BACTERICIDES; SIDE EFFECT REDUCTION | THE PROCTER & GAMBLE CO. | 2002-05-14 | — | — | US | disclosed |
| US-20020049192-A1 | Antimicrobial quinolones, their compositions and uses | THE PROCTER & GAMBLE COMPANY | 2002-04-25 | — | — | US | disclosed |
| US-6348624-B1 | TREATING 1-BROMO-2,4-DIFLUOROBENZENE WITH STRONG, NON-NUCLEOPHILIC BASE, REACTING WITH ELECTROPHILIC REAGENT, TREATING WITH ALKALI OR ALKALINE EARTH METAL OR ORGANOMETALLIC REAGENT AND CARBON DIOXIDE, OR FORMYLATING AND OXIDIZING | THE PROCTER & GAMBLE CO. | 2002-02-19 | — | — | US | disclosed |
| US-6329391-B1 | ANTIBIOTICS, BACTERICIDES USING QUINOLONES | THE PROCTER & GAMBLE CO. | 2001-12-11 | — | — | US | disclosed |
| EP-1045823-A1 | PROCESS FOR MAKING CERTAIN BENZOIC ACID COMPOUNDS | THE PROCTER & GAMBLE COMPANY (US) | 2000-10-25 | — | — | EP | disclosed |
| EP-1015445-A1 | ANTIMICROBIAL QUINOLONES, THEIR COMPOSITIONS AND USES | THE PROCTER & GAMBLE COMPANY (US) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999035117-A1 | PROCESS FOR MAKING CERTAIN BENZOIC ACID COMPOUNDS | THE PROCTER & GAMBLE COMPANY (US) | 1999-07-15 | — | — | WO | disclosed |
| WO-1999014214-A1 | ANTIMICROBIAL QUINOLONES, THEIR COMPOSITIONS AND USES | THE PROCTER & GAMBLE COMPANY (US) | 1999-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049192-A1 | Antimicrobial quinolones, their compositions and uses | QARS1, TOP1, TOP2A | DTYMK 847/4885ALDH1A1 3377/4885CYP1A2 430/4885 |
| US-20120277277-A1 | Methods of Treating a Hyperproliferative Disorder or Inhibiting Cell Growth in a Mammal | PCNA, MKI67, HRAS | DTYMK 227/4885ALDH1A1 1413/4885CYP1A2 4631/4885 |
| US-20020173501-A1 | Antimicrobial quinolones, their compositions and uses | QARS1, TOP1, TOP2A | DTYMK 847/4885ALDH1A1 3377/4885CYP1A2 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.