Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14679398 | 0.78 | CA1 (0.64) | SMN1; SMN2NPC1LMNAKMT2AMEN1 | |
| SCHEMBL10048212 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1MAPTLMNAKMT2A | |
| SCHEMBL16216296 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1MAPTLMNAKMT2A | |
| SCHEMBL4100287 | 0.75 | IDO1 (0.52) | SMN1; SMN2NPC1MAPTLMNAKMT2A | |
| SCHEMBL20113982 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1MAPTLMNAKMT2A | |
| Hydrochloric Acid SCHEMBL19520755 | 0.73 | IDO1 (0.53) | SMN1; SMN2NPC1MAPTLMNAKMT2A | |
| Hydrochloric Acid SCHEMBL4798435 | 0.73 | NPC1 (0.53) | SMN1; SMN2NPC1MAPTLMNAKMT2A | |
| SCHEMBL563548 | 0.73 | LMNA (0.50) | SMN1; SMN2NPC1MAPTLMNAKMT2A | |
| SCHEMBL18624786 | 0.73 | LMNA (0.46) | SMN1; SMN2NPC1MAPTLMNAKMT2A | |
| SCHEMBL296509 | 0.73 | MAPT (0.56) | SMN1; SMN2NPC1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020742-A1 | NOVEL HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | 塩野義製薬株式会社 (JP) | 2012-02-16 | — | — | WO | disclosed |